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Modular composition of the SGOCP.   (A)  Scheme of the multimodular composi...
Published: 05 November 2019
Figure 1. Modular composition of the SGOCP. (A) Scheme of the multimodular composition of the SGOCP, indicating its main inputs (orange) and outputs (blue) of the metabolic network. (B) Glycolysis and de novo serine synthesis modules coupled to the folate cycle. (C) Cytosolic and mitochond... More
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Sources of one-carbon units.  Routes of entry of one-carbon units from the ...
Published: 05 November 2019
Figure 2. Sources of one-carbon units. Routes of entry of one-carbon units from the catabolism of amino acids, from metabolic pathways that detoxify secondary toxic byproducts and from those that prevent degradation of folate species. Toxic byproducts are colored in red. Degraded folate species ... More
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Products of the SGOCP.   (A)  Metabolic reactions and upstream regulators t...
Published: 05 November 2019
Figure 3. Products of the SGOCP. (A) Metabolic reactions and upstream regulators that control SAM synthesis. (B) The mitochondrial folate cycle module that contributes to the generation of mature tRNAs for the translation of mitochondrial-coded proteins. (C) Reactions that control sphingol... More
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Regulation of the SGOCP.   (A and B)  Schematic showing the SGOCP regulatio...
Published: 05 November 2019
Figure 4. Regulation of the SGOCP. (A and B) Schematic showing the SGOCP regulation in nutrient-poor (A) and nutrient-rich (B) conditions. (A) Nutrient or ER stress activates the prosurvival functions of ATF4 by increasing nutrient uptake and promoting the machinery of intracellular amino ac... More
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