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Neutrophils in an autopsy specimen from the lungs of a patient who
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Published: 16 April 2020
Figure 1. Neutrophils in an autopsy specimen from the lungs of a patient who succumbed from COVID-19. (A) Extensive neutrophil infiltration in pulmonary capillaries, with acute capillaritis with fibrin deposition, and extravasation into the ... More
Images
Neutrophils forming NETs in cell culture.  Note the expelled
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Published: 16 April 2020
Figure 2. Neutrophils forming NETs in cell culture. Note the expelled DNA strings (arrows). Scanning electron microscopy of neutrophils 3 h after plating and coculturing with 4T1 breast cancer cells. Scale bar: 2... More
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Excess NET formation can drive a variety of severe
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Published: 16 April 2020
Figure 3. Excess NET formation can drive a variety of severe pathologies. In the lungs, NETs drive the accumulation of mucus in CF patients’ airways. NETs also drive ARDS after a variety of inducers, includin... More
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Approaches to targeting NETs.  NETs can be targeted by
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Published: 16 April 2020
Figure 4. Approaches to targeting NETs. NETs can be targeted by existing drugs through several means. NE, PAD4, and gasdermin D inhibitors will prevent NET formation. DNase has been used safely to digest NETs in ... More
Journal Articles