2020 Nobel Prize Collection
The Nobel Prize in Physiology or Medicine 2020 was awarded jointly to Charles M. Rice of The Rockefeller University, Michael Houghton of the University of Alberta, and Harvey J. Alter of the NIH for the discovery of Hepatitis C virus. Their contributions made possible blood tests and new medicines against blood-borne hepatitis, which is a major cause of liver cancer and cirrhosis. WHO estimated that in 2016, approximately 399,000 people died from hepatitis C, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer). While the statistics are sobering, many more lives would have been lost if it were not for seminal work by these scientists. We celebrate their winning the 2020 Nobel Prize in Physiology or Medicine with a collection of Journal of Experimental Medicine (JEM) and Journal of Cell Biology (JCB) studies published by Rice and Houghton on the topics of Hepatitis C virus, yellow fever, and SARS-CoV-2.
Illustration: Niklas Elmehed. © Nobel Media AB 2020
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
Naglaa H. Shoukry, Arash Grakoui, Michael Houghton, David Y. Chien, John Ghrayeb, Keith A. Reimann, Christopher M. WalkerDOI: 10.1084/jem.20030239
Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
M A Minutello, P Pileri, D Unutmaz, S Censini, G Kuo, M Houghton, M R Brunetto, F Bonino, S AbrignaniDOI: 10.1084/jem.178.1.17
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
Jérémie Decalf, Sandrine Fernandes, Randy Longman, Mina Ahloulay, Françoise Audat, François Lefrerre, Charles M. Rice, Stanislas Pol, Matthew L. AlbertDOI: 10.1084/jem.20070814
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes
Giovanna Barba-Spaeth, Randy S. Longman, Matthew L. Albert, Charles M. RiceDOI: 10.1084/jem.20051352
The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus
RC Piper, C Tai, JW Slot, CS Hahn, CM Rice, H Huang, DE JamesYellow fever 17D as a vaccine vector for microbial CTL epitopes : protection in a rodent malaria model
Deng Tao, Giovanna Barba-Spaeth, Urvashi Rai, Victor Nussenzweig, Charles M. Rice, Ruth S. NussenzweigInherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
Nicholas Hernandez, Giorgia Bucciol, Leen Moens, Jérémie Le Pen, Mohammad Shahrooei, Ekaterini Goudouris, Afshin Shirkani, Majid Changi-Ashtiani, Hassan Rokni-Zadeh, Esra Hazar Sayar, Ismail Reisli, Alain Lefevre-Utile, Dick Zijlmans, Andrea Jurado, Ruben Pholien, Scott Drutman, Serkan Belkaya, Aurelie Cobat, Robbert Boudewijns, Dirk Jochmans, Johan Neyts, Yoann Seeleuthner, Lazaro Lorenzo-Diaz, Chibuzo Enemchukwu, Ian Tietjen, Hans-Heinrich Hoffmann, Mana Momenilandi, Laura Pöyhönen, Marilda M. Siqueira, Sheila M. Barbosa de Lima, Denise C. de Souza Matos, Akira Homma, Maria de Lourdes S. Maia, Tamiris Azamor da Costa Barros, Patricia Mouta Nunes de Oliveira, Emersom Ciclini Mesquita, Rik Gijsbers, Shen-Ying Zhang, Stephen J. Seligman, Laurent Abel, Paul Hertzog, Nico Marr, Reinaldo de Menezes Martins, Isabelle Meyts, Qian Zhang, Margaret R. MacDonald, Charles M. Rice, Jean-Laurent Casanova, Emmanuelle Jouanguy, Xavier BossuytDOI: 10.1084/jem.20182295
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