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mEPSC recordings.  mEPSCs recorded from neurons (left), and from HEK cells ...
Published: 11 June 2024
Figure 1. mEPSC recordings. mEPSCs recorded from neurons (left), and from HEK cells (right) expressing postsynaptic proteins (GluA2, neuroligin 1, PSD-95, and stargazin) and co-cultured with neurons. Traces were drawn from the data of Chiang et More about this image found in mEPSC recordings. mEPSCs recorded from neurons (left), and from HEK cells ...
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Plots of mEPSC rise-time versus amplitude.  Scatter plots with each point r...
Published: 11 June 2024
Figure 2. Plots of mEPSC rise-time versus amplitude. Scatter plots with each point reflecting one mEPSC. (A) A plot of 3,170 points from neurons; linear regression yielded a slope of 0.0077 ± 0006 msec/pA (P < 0.0001); 135 points had More about this image found in Plots of mEPSC rise-time versus amplitude. Scatter plots with each point r...
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Cell–mean plots of rise-time versus amplitude, with each point representing...
Published: 11 June 2024
Figure 3. Cell–mean plots of rise-time versus amplitude, with each point representing the means for an individual cell. (A) Neurons: each point represents means of from 29 to 191 mEPSCs from an individual cell (mean = 109; slope = −0.0045 ± More about this image found in Cell–mean plots of rise-time versus amplitude, with each point representing...
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Cell variations in rise-time-versus-amplitude plots  . (A 1)  Rise-time-ver...
Published: 11 June 2024
Figure 4. Cell variations in rise-time-versus-amplitude plots . (A 1) Rise-time-versus-amplitude plot of 160 mEPSCs recorded from one neuron. Linear regression indicated a highly significant correlation (P < 0.0001). (A 2) Plot of 150 More about this image found in Cell variations in rise-time-versus-amplitude plots . (A 1) Rise-time-ver...
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Fusion pore flux and receptor dynamics.  (A)  Model for receptor activation...
Published: 11 June 2024
Figure 5. Fusion pore flux and receptor dynamics. (A) Model for receptor activation. Neurotransmitter molecules, A, bind to a receptor, R, which can interconvert to an open channel, O, or a desensitized state, D. Rate constants for the More about this image found in Fusion pore flux and receptor dynamics. (A) Model for receptor activation...
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Fusion pore flux,   receptor dynamics, and diffusion. (A)  A model for neur...
Published: 11 June 2024
Figure 6. Fusion pore flux, receptor dynamics, and diffusion. (A) A model for neurotransmitter flux and radial diffusion. Receptor activation is represented by Eqs. 1, A , B , C , D , E , and F , according to the kinetic model for GluA2 More about this image found in Fusion pore flux, receptor dynamics, and diffusion. (A) A model for neur...
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Plots of rise-time versus amplitude from simulations with N <sub> 0 </sub> ...
Published: 11 June 2024
Figure 7. Plots of rise-time versus amplitude from simulations with N 0 = 2,000–10,000. (A 1 and 2) Plots for R0 = 1,000–4,000 μm−2 with rp = 0.1 µm (A 1) and 0.4 µm (A 2), and α = 0.3 msec. Circles highlight points for N0 = 6,000 throughout More about this image found in Plots of rise-time versus amplitude from simulations with N 0 ...
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Recapitulation of HEK cell mEPSCs. (A)  An mEPSC was simulated with N<sub>0</sub>...
Published: 11 June 2024
Figure 8. Recapitulation of HEK cell mEPSCs. (A) An mEPSC was simulated with N0 = 6,000, rp = 0.2 µm, R0 = 1,970 receptors/µm2, α = 0.15 msec, and D = 0.3 µm2/msec. The peak amplitude was −32.76 pA and the rise-time was 0.334 msec, in agreement More about this image found in Recapitulation of HEK cell mEPSCs. (A) An mEPSC was simulated with N0...
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Recapitulation of mEPSCs in neurons. (A)  With GluA2 parameters from the le...
Published: 11 June 2024
Figure 9. Recapitulation of mEPSCs in neurons. (A) With GluA2 parameters from the legend of Fig. 5 , N0 = 6,000, rp = 0.2 µm, and D = 0.3 µm2/msec, R0 was adjusted to 1,800 μm−2 and α to 0.70 msec. The mEPSC (labeled GluA2) had a peak amplitude More about this image found in Recapitulation of mEPSCs in neurons. (A) With GluA2 parameters from the le...
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Acetylcholine increased postsynaptic currents (PSCs) in starburst amacrine ...
Published: 05 June 2024
Figure 1. Acetylcholine increased postsynaptic currents (PSCs) in starburst amacrine cells (SACs). (A) Schematic diagram showing a cross-section of the retina. ON or OFF SACs labeled by GFP (green) were targeted. ON and OFF SACs were identified More about this image found in Acetylcholine increased postsynaptic currents (PSCs) in starburst amacrine ...
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SR95531 blocked ACh-induced PSCs in SACs. (A and B)  Effects of SR95531 on ...
Published: 05 June 2024
Figure 2. SR95531 blocked ACh-induced PSCs in SACs. (A and B) Effects of SR95531 on ACh-induced PSCs in ON SACs (A) and OFF SACs (B). The open bar above the trace shows the timing of the SR95531 application. Thick black bars show the timing of More about this image found in SR95531 blocked ACh-induced PSCs in SACs. (A and B) Effects of SR95531 on ...
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A nicotinic agonist increased PSCs in SACs in young (P7–8) mice. (A and C) ...
Published: 05 June 2024
Figure 3. A nicotinic agonist increased PSCs in SACs in young (P7–8) mice. (A and C) Responses to nicotine (left) and oxotremorine (right) in ON SACs (A) and OFF SACs (C). The open bar above the trace shows the timing of the nicotine More about this image found in A nicotinic agonist increased PSCs in SACs in young (P7–8) mice. (A and C) ...
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In adult mice (≥P28), not only a nicotinic agonist, but also a muscarinic a...
Published: 05 June 2024
Figure 4. In adult mice (≥P28), not only a nicotinic agonist, but also a muscarinic agonist increased PSCs in ON SACs. (A and C) Responses to nicotine (left) and oxotremorine (right) in ON SACs (A) and OFF SACs (C). The open bar above the trace More about this image found in In adult mice (≥P28), not only a nicotinic agonist, but also a muscarinic a...
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ACh-induced PSCs were mediated by non-spiking amacrine cells. (A and B)  Ef...
Published: 05 June 2024
Figure 5. ACh-induced PSCs were mediated by non-spiking amacrine cells. (A and B) Effects of TTX on ACh-induced PSCs in an ON SAC (A) and an OFF SAC (B). Open bars above the trace show the timing of the TTX application. Thick black bars show the More about this image found in ACh-induced PSCs were mediated by non-spiking amacrine cells. (A and B) Ef...
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ACh-induced PSCs were mediated by amacrine cells other than SACs. (A and B)...
Published: 05 June 2024
Figure 6. ACh-induced PSCs were mediated by amacrine cells other than SACs. (A and B) Effects of LY354740 on ACh-induced PSCs in an ON SAC (A) and an OFF SAC (B). Open bars above the trace show the timing of the LY354740 application. Thick black More about this image found in ACh-induced PSCs were mediated by amacrine cells other than SACs. (A and B)...
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ON and OFF SACs receive distinct synaptic inputs.  Schematic drawing of syn...
Published: 05 June 2024
Figure 7. ON and OFF SACs receive distinct synaptic inputs. Schematic drawing of synaptic wiring in ON and OFF SACs (green cells) in the adult mouse retina. ON and OFF SACs both receive nicotinic receptor-mediated GABAergic inputs (blue) and More about this image found in ON and OFF SACs receive distinct synaptic inputs. Schematic drawing of syn...
Journal Articles