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Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Correction: How could simulations elucidate Nav1.5 channel blockers mechanism?

Tanadet Pipatpolkai
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e20241373001082025c.
https://doi.org/10.1085/jgp.20241373001082025c
Published: 16 January 2025
View article titled, Correction: How could simulations elucidate Na<sub>v</sub>1.5 channel blockers mechanism?
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Journal Articles

How could simulations elucidate Nav1.5 channel blockers mechanism?

Tanadet Pipatpolkai
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413730.
https://doi.org/10.1085/jgp.202413730
Published: 07 January 2025
View article titled, How could simulations elucidate Na<sub>v</sub>1.5 channel blockers mechanism?
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Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Na<sub>v</sub>1.5 cardiac sodium channel pore
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Journal Articles

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313472.
https://doi.org/10.1085/jgp.202313472
Published: 31 December 2024
View article titled, The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Includes: Supplementary data
Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View article titled, Reduced voltage-activated Ca<sup>2+</sup> release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers

Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413676.
https://doi.org/10.1085/jgp.202413676
Published: 20 December 2024
View article titled, Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers
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Journal Articles

Correction: Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Wessel A.C. Burger, Patrick M. Sexton, Arthur Christopoulos, David M. Thal
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e20171197912022024c.
https://doi.org/10.1085/jgp.20171197912022024c
Published: 19 December 2024
View article titled, Correction: Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
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Journal Articles

How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore

Elizabeth Murphy, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313520.
https://doi.org/10.1085/jgp.202313520
Published: 19 December 2024
View article titled, How does mitochondrial Ca<sup>2+</sup> change during ischemia and reperfusion? Implications for activation of the permeability transition pore
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Journal Articles

A misstep in the multistep process of fast inactivation

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413735.
https://doi.org/10.1085/jgp.202413735
Published: 17 December 2024
View article titled, A misstep in the multistep process of fast inactivation
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Journal Articles

Intrinsic adaptive plasticity in mouse and human sensory neurons

Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou, Tayler D. Sheahan, Andrew J. Shepherd, Richard A. Slivicki, John A. Lemen, Theodore J. Price, Bryan A. Copits, Robert W. Gereau, IV
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 157 (1): e202313488.
https://doi.org/10.1085/jgp.202313488
Published: 17 December 2024
View article titled, Intrinsic adaptive plasticity in mouse and human sensory neurons
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View article titled, Isoform-specific N-linked glycosylation of Na<sub>V</sub> channel α-subunits alters β-subunit binding sites
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Journal Articles

Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy

Joan A. Chan, Michelle L. Munro
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413673.
https://doi.org/10.1085/jgp.202413673
Published: 12 December 2024
View article titled, Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy
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Journal Articles

Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

Amy D. Hanna, Ting Chang, Kevin S. Ho, Rachel Sue Zhen Yee, William Cameron Walker, Nadia Agha, Chih-Wei Hsu, Sung Yun Jung, Mary E. Dickinson, Md. Abul Hassan Samee, Christopher S. Ward, Chang Seok Lee, George G. Rodney, Susan L. Hamilton
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413583.
https://doi.org/10.1085/jgp.202413583
Published: 11 December 2024
View article titled, Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency
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Includes: Supplementary data
Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

Yichen Liu, Francisco Bezanilla
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413667.
https://doi.org/10.1085/jgp.202413667
Published: 27 November 2024
View article titled, A sodium channel mutant removes fast inactivation with the inactivation particle bound
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Includes: Supplementary data
Journal Articles

Null method to estimate the maximal PA at subsaturating concentrations of agonist

Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413644.
https://doi.org/10.1085/jgp.202413644
Published: 25 November 2024
View article titled, Null method to estimate the maximal P<sub>A</sub> at subsaturating concentrations of agonist
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Journal Articles

Regulation of NMDAR activation efficiency by environmental factors and subunit composition

Miaomiao He, Lonnie P. Wollmuth
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413637.
https://doi.org/10.1085/jgp.202413637
Published: 22 November 2024
View article titled, Regulation of NMDAR activation efficiency by environmental factors and subunit composition
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Journal Articles

A new stress test for ryanodine receptors

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202413716.
https://doi.org/10.1085/jgp.202413716
Published: 19 November 2024
View article titled, A new stress test for ryanodine receptors
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Journal Articles

Stochastic force generation in an isometric binary mechanical system

Vidya Murthy, Josh E. Baker
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313493.
https://doi.org/10.1085/jgp.202313493
Published: 19 November 2024
View article titled, Stochastic force generation in an isometric binary mechanical system
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Includes: Supplementary data