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Journal Articles

Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders

Christian Jorgensen
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413744.
https://doi.org/10.1085/jgp.202413744
Published: 23 January 2025
View article titled, Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders
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Journal Articles

How could simulations elucidate Nav1.5 channel blockers mechanism?

Tanadet Pipatpolkai
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413730.
https://doi.org/10.1085/jgp.202413730
Published: 07 January 2025
View article titled, How could simulations elucidate Na<sub>v</sub>1.5 channel blockers mechanism?
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Journal Articles

Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy

Joan A. Chan, Michelle L. Munro
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413673.
https://doi.org/10.1085/jgp.202413673
Published: 12 December 2024
View article titled, Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy
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Journal Articles

Myosin-binding protein-H: Not just filler

David Y. Barefield
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202413622.
https://doi.org/10.1085/jgp.202413622
Published: 01 November 2024
View article titled, Myosin-binding protein-H: Not just filler
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Journal Articles

What happened to the pursuit of truth?

Eve Marder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413672.
https://doi.org/10.1085/jgp.202413672
Published: 23 October 2024
View article titled, What happened to the pursuit of truth?
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Journal Articles

Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes

Cherrie H.T. Kong, Eef Dries
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202413629.
https://doi.org/10.1085/jgp.202413629
Published: 22 August 2024
View article titled, Rad protein: An essential player in L-type Ca<sup>2+</sup> channel localization and modulation in cardiomyocytes
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Journal Articles

Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy

Danuta Szczesna-Cordary
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202413640.
https://doi.org/10.1085/jgp.202413640
Published: 12 August 2024
View article titled, Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy
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Journal Articles

Beyond homogenates: New tool available for estimating glycogen’s numerical subcellular distribution

Joachim Nielsen
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202413607.
https://doi.org/10.1085/jgp.202413607
Published: 09 July 2024
View article titled, Beyond homogenates: New tool available for estimating glycogen’s numerical subcellular distribution
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Journal Articles

On the link between antibiotic resistance, diabetes, and wastewater

Shimon Schuldiner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (3): e202313533.
https://doi.org/10.1085/jgp.202313533
Published: 31 January 2024
View article titled, On the link between antibiotic resistance, diabetes, and wastewater
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Journal Articles

Changing face of contractile activation in striated muscle at physiological temperature

Alf Månsson
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (12): e202313494.
https://doi.org/10.1085/jgp.202313494
Published: 07 November 2023
View article titled, Changing face of contractile activation in striated muscle at physiological temperature
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Journal Articles

Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

Nathaniel Smith, Han Sun
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (11): e202313481.
https://doi.org/10.1085/jgp.202313481
Published: 13 October 2023
View article titled, Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels
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Journal Articles

Different species, different gap junctions?

Rafael Sanz-Gálvez, Arlette Kolta
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (9): e202313430.
https://doi.org/10.1085/jgp.202313430
Published: 01 August 2023
View article titled, Different species, different gap junctions?
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Journal Articles

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Wout J. Claassen, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (7): e202213292.
https://doi.org/10.1085/jgp.202213292
Published: 16 May 2023
View article titled, Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres
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Journal Articles

Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit

Miaomiao He, Lonnie P. Wollmuth
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313391.
https://doi.org/10.1085/jgp.202313391
Published: 03 May 2023
View article titled, Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit
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Journal Articles

How can AI accelerate advances in physiology?

Andrew D. McCulloch
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (6): e202313388.
https://doi.org/10.1085/jgp.202313388
Published: 27 April 2023
View article titled, How can AI accelerate advances in physiology?
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Journal Articles

Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients

Tinatin I. Brelidze
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313333.
https://doi.org/10.1085/jgp.202313333
Published: 14 April 2023
View article titled, Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients
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Journal Articles

Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation

László Csanády
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313336.
https://doi.org/10.1085/jgp.202313336
Published: 05 April 2023
View article titled, Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation
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Journal Articles

Tweaking the catalytic efficiency of the CFTR ion channel

In Special Collection:
Molecular Insights into Membrane Protein Function
Nael A. McCarty
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202313343.
https://doi.org/10.1085/jgp.202313343
Published: 04 April 2023
View article titled, Tweaking the catalytic efficiency of the CFTR ion channel
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Journal Articles

Sensing its own permeant ion: KCNQ1 channel inhibition by external K+

In Special Collection:
Physiology of Pain Detection and Processing Collection 2023
Rene Barro-Soria
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202313337.
https://doi.org/10.1085/jgp.202313337
Published: 24 March 2023
View article titled, Sensing its own permeant ion: KCNQ1 channel inhibition by external K<sup>+</sup>
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Journal Articles

Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?

David Y. Barefield
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (4): e202313351.
https://doi.org/10.1085/jgp.202313351
Published: 22 March 2023
View article titled, Is haploinsufficiency a sufficient mechanism for <em>MYBPC3</em> truncating mutations?
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