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Journal Articles

Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias

Josè Manuel Pioner, Enrico Pierantozzi, Raffaele Coppini, Egidio Maria Rubino, Valentina Biasci, Giulia Vitale, Annunziatina Laurino, Lorenzo Santini, Marina Scardigli, Davide Randazzo, Camilla Olianti, Matteo Serano, Daniela Rossi, Chiara Tesi, Elisabetta Cerbai, Stephan Lange, Carlo Reggiani, Leonardo Sacconi, Corrado Poggesi, Cecilia Ferrantini, Vincenzo Sorrentino
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413696.
https://doi.org/10.1085/jgp.202413696
Published: 14 May 2025
View articletitled, Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias
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Includes: Supplementary data
Journal Articles

Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility

Seong-Won Han, Justin Kolb, Gerrie P. Farman, Jochen Gohlke, Henk L. Granzier
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413729.
https://doi.org/10.1085/jgp.202413729
Published: 09 May 2025
View articletitled, Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility
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Includes: Supplementary data
Journal Articles

Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413597.
https://doi.org/10.1085/jgp.202413597
Published: 05 May 2025
View articletitled, Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons
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Includes: Supplementary data
Journal Articles

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)

John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202513778.
https://doi.org/10.1085/jgp.202513778
Published: 28 April 2025
View articletitled, Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
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Journal Articles

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413641.
https://doi.org/10.1085/jgp.202413641
Published: 24 April 2025
View articletitled, Prediction and biological significance of small changes in binding of leiomodin to tropomyosin
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Includes: Supplementary data
Journal Articles

A realistic look at rod synapses

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202513804.
https://doi.org/10.1085/jgp.202513804
Published: 16 April 2025
View articletitled, A realistic look at rod synapses
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Journal Articles

Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826

Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert G. Stewart, Patric M. Vaelli, Bruce P. Bean
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413719.
https://doi.org/10.1085/jgp.202413719
Published: 26 March 2025
View articletitled, Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826
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Journal Articles

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413678.
https://doi.org/10.1085/jgp.202413678
Published: 24 March 2025
View articletitled, Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
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Journal Articles

How the Blind Watchmaker messed around with potassium channels

Lawrence Salkoff
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202513783.
https://doi.org/10.1085/jgp.202513783
Published: 19 March 2025
View articletitled, How the Blind Watchmaker messed around with potassium channels
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Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View articletitled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band

Dalma Kellermayer, Cristina M. Șulea, Hedvig Tordai, Kálmán Benke, Miklós Pólos, Bence Ágg, Roland Stengl, Máté Csonka, Tamás Radovits, Béla Merkely, Zoltán Szabolcs, Miklós Kellermayer, Balázs Kiss
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413690.
https://doi.org/10.1085/jgp.202413690
Published: 10 March 2025
View articletitled, Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band
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Includes: Supplementary data
Journal Articles

Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression

Lucian Medrihan, Margarete G. Knudsen, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa, Paul Greengard, Ana Milosevic
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413693.
https://doi.org/10.1085/jgp.202413693
Published: 07 March 2025
View articletitled, Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression
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Journal Articles

Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Morris Vysma, James S. Welsh, Derek R. Laver
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413543.
https://doi.org/10.1085/jgp.202413543
Published: 06 March 2025
View articletitled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model
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Includes: Supplementary data
Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413746.
https://doi.org/10.1085/jgp.202413746
Published: 28 February 2025
View articletitled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses
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Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202313506.
https://doi.org/10.1085/jgp.202313506
Published: 21 February 2025
View articletitled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel
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Includes: Supplementary data
Journal Articles

A complete set of rate constants for a transporter’s catalytic cycle

Michael L. Jennings
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202513766.
https://doi.org/10.1085/jgp.202513766
Published: 21 February 2025
View articletitled, A complete set of rate constants for a transporter’s catalytic cycle
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Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View articletitled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

FAT3 provides a flicker of light

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202513772.
https://doi.org/10.1085/jgp.202513772
Published: 11 February 2025
View articletitled, FAT3 provides a flicker of light
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Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (2): e202413684.
https://doi.org/10.1085/jgp.202413684
Published: 07 February 2025
View articletitled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
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Includes: Supplementary data
Journal Articles

PANX1 hexamers work but cells prefer heptamers

Andrew L. Harris
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413727.
https://doi.org/10.1085/jgp.202413727
Published: 05 February 2025
View articletitled, PANX1 hexamers work but cells prefer heptamers
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