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Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513800.
https://doi.org/10.1085/jgp.202513800
Published: 11 November 2025
View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry
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Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513761.
https://doi.org/10.1085/jgp.202513761
Published: 03 November 2025
View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
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Includes: Supplementary data
Journal Articles

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W. York, Robert C. Tryon, Gretchen A. Meyer, Colin G. Nichols
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513781.
https://doi.org/10.1085/jgp.202513781
Published: 07 October 2025
View article titled, Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice
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Journal Articles

Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers

Philip C. Woods, Douglas M. Swank, Mark S. Miller
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413679.
https://doi.org/10.1085/jgp.202413679
Published: 11 August 2025
View article titled, Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers
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Journal Articles

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

Martin C. Heiss, Monica L. Fernández-Quintero, Marta Campiglio, Yousra El Ghaleb, Simone Pelizzari, Johannes R. Loeffler, Klaus R. Liedl, Petronel Tuluc, Bernhard E. Flucher
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513769.
https://doi.org/10.1085/jgp.202513769
Published: 04 August 2025
View article titled, Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation
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Includes: Supplementary data
Journal Articles

Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility

Seong-Won Han, Justin Kolb, Gerrie P. Farman, Jochen Gohlke, Henk L. Granzier
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413729.
https://doi.org/10.1085/jgp.202413729
Published: 09 May 2025
View article titled, Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility
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Includes: Supplementary data
Journal Articles

Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413610.
https://doi.org/10.1085/jgp.202413610
Published: 04 February 2025
View article titled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis
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Includes: Supplementary data
Journal Articles

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313472.
https://doi.org/10.1085/jgp.202313472
Published: 31 December 2024
View article titled, The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Includes: Supplementary data
Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View article titled, Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

Amy D. Hanna, Ting Chang, Kevin S. Ho, Rachel Sue Zhen Yee, William Cameron Walker, Nadia Agha, Chih-Wei Hsu, Sung Yun Jung, Mary E. Dickinson, Md. Abul Hassan Samee, Christopher S. Ward, Chang Seok Lee, George G. Rodney, Susan L. Hamilton
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413583.
https://doi.org/10.1085/jgp.202413583
Published: 11 December 2024
View article titled, Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency
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Includes: Supplementary data
Journal Articles

Stochastic force generation in an isometric binary mechanical system

Vidya Murthy, Josh E. Baker
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313493.
https://doi.org/10.1085/jgp.202313493
Published: 19 November 2024
View article titled, Stochastic force generation in an isometric binary mechanical system
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Includes: Supplementary data
Journal Articles

Stable oxidative posttranslational modifications alter the gating properties of RyR1

Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313515.
https://doi.org/10.1085/jgp.202313515
Published: 05 November 2024
View article titled, Stable oxidative posttranslational modifications alter the gating properties of RyR1
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Includes: Supplementary data
Journal Articles

Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

Andrew F. Mead, Neil B. Wood, Shane R. Nelson, Bradley M. Palmer, Lin Yang, Samantha Beck Previs, Angela Ploysangngam, Guy G. Kennedy, Jennifer F. McAdow, Sarah M. Tremble, Marcus A. Zimmermann, Marilyn J. Cipolla, Alicia M. Ebert, Aaron N. Johnson, Christina A. Gurnett, Michael J. Previs, David M. Warshaw
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2024) 156 (12): e202413604.
https://doi.org/10.1085/jgp.202413604
Published: 07 October 2024
View article titled, Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle
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Includes: Supplementary data
Journal Articles

Using neural networks for image analysis in general physiology

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202413623.
https://doi.org/10.1085/jgp.202413623
Published: 17 September 2024
View article titled, Using neural networks for image analysis in general physiology
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Journal Articles

A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice

Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313486.
https://doi.org/10.1085/jgp.202313486
Published: 04 March 2024
View article titled, A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice
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Includes: Supplementary data
Journal Articles

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy

Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313471.
https://doi.org/10.1085/jgp.202313471
Published: 20 February 2024
View article titled, Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy
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Includes: Supplementary data