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Myofilament Special Issue, 2020
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Journal Articles

Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle

Massimo Reconditi, Elisabetta Brunello, Luca Fusi, Marco Linari, Vincenzo Lombardi, Malcolm Irving, Gabriella Piazzesi
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (11): e202112896.
https://doi.org/10.1085/jgp.202112896
Published: 20 October 2021
View articletitled, Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle
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Journal Articles

Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction

John M. Squire, Carlo Knupp
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (10): e202012778.
https://doi.org/10.1085/jgp.202012778
Published: 05 August 2021
View articletitled, Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction
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Journal Articles

The muscle M3 x-ray diffraction peak and sarcomere length: No evidence for disordered myosin heads out of actin overlap

John M. Squire, Carlo Knupp
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (10): e202012859.
https://doi.org/10.1085/jgp.202012859
Published: 04 August 2021
View articletitled, The muscle M3 x-ray diffraction peak and sarcomere length: No evidence for disordered myosin heads out of actin overlap
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Journal Articles

Further progress in understanding of myofibrillar function in health and disease

Christine Cremo, Richard L. Moss, Henk Granzier
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202112972.
https://doi.org/10.1085/jgp.202112972
Published: 25 June 2021
View articletitled, Further progress in understanding of myofibrillar function in health and disease
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Journal Articles

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator

In Special Collection:
Biophysics 2022
Robbert J. van der Pijl, Marloes van den Berg, Martijn van de Locht, Shengyi Shen, Sylvia J.P. Bogaards, Stefan Conijn, Paul Langlais, Pleuni E. Hooijman, Siegfried Labeit, Leo M.A. Heunks, Henk Granzier, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202112925.
https://doi.org/10.1085/jgp.202112925
Published: 21 June 2021
View articletitled, Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator
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Includes: Supplementary data
Journal Articles

cMyBPC phosphorylation alters response to heart failure drug

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202112973.
https://doi.org/10.1085/jgp.202112973
Published: 14 June 2021
View articletitled, cMyBPC phosphorylation alters response to heart failure drug
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Journal Articles

Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle

Sandra Pütz, Lisa Sophie Barthel, Marina Frohn, Doris Metzler, Mohammed Barham, Galyna Pryymachuk, Oliver Trunschke, Lubomir T. Lubomirov, Jürgen Hescheler, Joseph M. Chalovich, Wolfram F. Neiss, Manuel Koch, Mechthild M. Schroeter, Gabriele Pfitzer
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012776.
https://doi.org/10.1085/jgp.202012776
Published: 11 June 2021
View articletitled, Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle
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Journal Articles

Why make a strong muscle weaker?

Bogdan Iorga, Theresia Kraft
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202112928.
https://doi.org/10.1085/jgp.202112928
Published: 09 June 2021
View articletitled, Why make a strong muscle weaker?
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Journal Articles

Titin–N2A: More than a signaling node?

Robbert J. van der Pijl, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202112904.
https://doi.org/10.1085/jgp.202112904
Published: 03 June 2021
View articletitled, Titin–N2A: More than a signaling node?
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Journal Articles

Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin

Yoel H. Sitbon, Francisca Diaz, Katarzyna Kazmierczak, Jingsheng Liang, Medhi Wangpaichitr, Danuta Szczesna-Cordary
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012801.
https://doi.org/10.1085/jgp.202012801
Published: 20 May 2021
View articletitled, Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin
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Includes: Supplementary data
Journal Articles

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Giulia Vitale, Josè Manuel Pioner, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012789.
https://doi.org/10.1085/jgp.202012789
Published: 23 April 2021
View articletitled, Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle
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Journal Articles

Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin

In Special Collection:
Cardiac Physiology 2021
David V. Rasicci, Orville Kirkland, Jr., Faruk H. Moonschi, Neil B. Wood, Danuta Szczesna-Cordary, Michael J. Previs, Jonathan F. Wenk, Kenneth S. Campbell, Christopher M. Yengo
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012811.
https://doi.org/10.1085/jgp.202012811
Published: 23 April 2021
View articletitled, Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin
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Journal Articles

Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium

Farbod Fazlollahi, Jorge J. Santini Gonzalez, Steven J. Repas, Benjamin D. Canan, George E. Billman, Paul M.L. Janssen
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012829.
https://doi.org/10.1085/jgp.202012829
Published: 13 April 2021
View articletitled, Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium
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Journal Articles

The N2A region of titin has a unique structural configuration

In Special Collection:
Biophysics 2022
Chiara Stronczek, Stephan Lange, Belinda Bullard, Sebastian Wolniak, Emma Börgeson, Olga Mayans, Jennifer R. Fleming
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012766.
https://doi.org/10.1085/jgp.202012766
Published: 09 April 2021
View articletitled, The N2A region of titin has a unique structural configuration
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Journal Articles

Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

Andrew K. Coleman, Humberto C. Joca, Guoli Shi, W. Jonathan Lederer, Christopher W. Ward
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012743.
https://doi.org/10.1085/jgp.202012743
Published: 19 March 2021
View articletitled, Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle
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Includes: Supplementary data
Journal Articles

Novel insights into sarcomere regulatory systems control of cardiac thin filament activation

Christopher Solís, R. John Solaro
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012777.
https://doi.org/10.1085/jgp.202012777
Published: 19 March 2021
View articletitled, Novel insights into sarcomere regulatory systems control of cardiac thin filament activation
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Journal Articles

cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation

Ranganath Mamidi, Joshua B. Holmes, Chang Yoon Doh, Katherine L. Dominic, Nikhil Madugula, Julian E. Stelzer
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012816.
https://doi.org/10.1085/jgp.202012816
Published: 10 March 2021
View articletitled, cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation
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Journal Articles

Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts

In Special Collection:
Cardiac Physiology 2021
Laurin M. Hanft, Daniel P. Fitzsimons, Timothy A. Hacker, Richard L. Moss, Kerry S. McDonald
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (7): e202012770.
https://doi.org/10.1085/jgp.202012770
Published: 01 March 2021
View articletitled, Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts
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Journal Articles

Toward an understanding of myofibrillar function in health and disease

Richard L. Moss, Christine Cremo, Henk L. Granzier
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (3): e202112880.
https://doi.org/10.1085/jgp.202112880
Published: 23 February 2021
View articletitled, Toward an understanding of myofibrillar function in health and disease
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Journal Articles

Filament evanescence of myosin II and smooth muscle function

Lu Wang, Pasquale Chitano, Chun Y. Seow
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (3): e202012781.
https://doi.org/10.1085/jgp.202012781
Published: 19 February 2021
View articletitled, Filament evanescence of myosin II and smooth muscle function
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