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Journal Articles

Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

J Gen Physiol (2023) 155 (7): e202213268.

https://doi.org/10.1085/jgp.202213268

Published: 25 May 2023

View article titled, Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

Includes: Supplementary data

Journal Articles

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Wout J. Claassen, Coen A.C. Ottenheijm

J Gen Physiol (2023) 155 (7): e202213292.

https://doi.org/10.1085/jgp.202213292

Published: 16 May 2023

View article titled, Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Journal Articles

How can AI accelerate advances in physiology?

Andrew D. McCulloch

J Gen Physiol (2023) 155 (6): e202313388.

https://doi.org/10.1085/jgp.202313388

Published: 27 April 2023

View article titled, How can AI accelerate advances in physiology?

Journal Articles

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

Sukriti Dewan, Namthip Witayavanitkul, Mohit Kumar, Beth J. Mayer, Lauren Betancourt, Olivier Cazorla, Pieter P. de Tombe

J Gen Physiol (2023) 155 (6): e202213288.

https://doi.org/10.1085/jgp.202213288

Published: 27 April 2023

View article titled, Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

Includes: Supplementary data

Journal Articles

The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

Katherine L. Dominic, Joohee Choi, Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer

J Gen Physiol (2023) 155 (6): e202213318.

https://doi.org/10.1085/jgp.202213318

Published: 17 April 2023

View article titled, The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

Journal Articles

Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts

Laurin M. Hanft, Joel C. Robinett, Theodore J. Kalogeris, Kenneth S. Campbell, Brandon J. Biesiadecki, Kerry S. McDonald

J Gen Physiol (2023) 155 (5): e202213290.

https://doi.org/10.1085/jgp.202213290

Published: 31 March 2023

View article titled, Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts

Includes: Supplementary data

Journal Articles

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Anthony Asencio, Sage Malingen, Kristina B. Kooiker, Joseph D. Powers, Jennifer Davis, Thomas Daniel, Farid Moussavi-Harami

J Gen Physiol (2023) 155 (5): e202213291.

https://doi.org/10.1085/jgp.202213291

Published: 31 March 2023

View article titled, Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Journal Articles

Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?

David Y. Barefield

J Gen Physiol (2023) 155 (4): e202313351.

https://doi.org/10.1085/jgp.202313351

Published: 22 March 2023

View article titled, Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?

Journal Articles

cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca²⁺-handling abnormalities

Willem J. De Lange, Emily T. Farrell, Jonathan J. Hernandez, Alana Stempien, Caroline R. Kreitzer, Derek R. Jacobs, Dominique L. Petty, Richard L. Moss, Wendy C. Crone, J. Carter Ralphe

J Gen Physiol (2023) 155 (4): e202213204.

https://doi.org/10.1085/jgp.202213204

Published: 09 March 2023

View article titled, cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities

Includes: Supplementary data

Journal Articles

RLC phosphorylation amplifies Ca²⁺ sensitivity of force in myocardium from cMyBP-C knockout mice

Kyrah L. Turner, Haley S. Morris, Peter O. Awinda, Daniel P. Fitzsimons, Bertrand C.W. Tanner

J Gen Physiol (2023) 155 (4): e202213250.

https://doi.org/10.1085/jgp.202213250

Published: 30 January 2023

View article titled, RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice

Includes: Supplementary data

Journal Articles

Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging

Oleg Lookin, Pieter de Tombe, Najlae Boulali, Csilla Gergely, Thierry Cloitre, Olivier Cazorla

J Gen Physiol (2023) 155 (4): e202213289.

https://doi.org/10.1085/jgp.202213289

Published: 25 January 2023

View article titled, Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging

Journal Articles

Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle

In Special Collection:

Biophysics 2024

Shane Nelson, Samantha Beck-Previs, Sakthivel Sadayappan, Carl Tong, David M. Warshaw

J Gen Physiol (2023) 155 (4): e202213276.

https://doi.org/10.1085/jgp.202213276

Published: 23 January 2023

View article titled, Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle

Includes: Supplementary data

Journal Articles

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Alexey V. Dvornikov, Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson

J Gen Physiol (2023) 155 (3): e202113054.

https://doi.org/10.1085/jgp.202113054

Published: 12 January 2023

View article titled, Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Includes: Supplementary data

Journal Articles

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Matthew H. Doran, Michael J. Rynkiewicz, David Rasicci, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt, Christopher M. Yengo, Jeffrey R. Moore, William Lehman

J Gen Physiol (2023) 155 (3): e202213267.

https://doi.org/10.1085/jgp.202213267

Published: 12 January 2023

View article titled, Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Journal Articles

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Seetharamaiah Attili, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell

J Gen Physiol (2023) 155 (3): e202213200.

https://doi.org/10.1085/jgp.202213200

Published: 12 January 2023

View article titled, Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium

Includes: Supplementary data

Journal Articles

Calcium activation through thick and thin?

Michael J. Previs

J Gen Physiol (2022) 155 (1): e202213265.

https://doi.org/10.1085/jgp.202213265

Published: 16 December 2022

View article titled, Calcium activation through thick and thin?

Journal Articles

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Matthew H. Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David Rasicci, Jeffrey R. Moore, Christopher M. Yengo, Esther Bullitt, William Lehman

J Gen Physiol (2022) 155 (2): e202213274.

https://doi.org/10.1085/jgp.202213274

Published: 02 December 2022

View article titled, Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Includes: Supplementary data

Journal Articles

Variants of the myosin interacting-heads motif

Raúl Padrón, Debabrata Dutta, Roger Craig

J Gen Physiol (2022) 155 (1): e202213249.

https://doi.org/10.1085/jgp.202213249

Published: 08 November 2022

View article titled, Variants of the myosin interacting-heads motif

Journal Articles

Cardiac myosin filaments are directly regulated by calcium

In Special Collection:

Biophysics 2023

Weikang Ma, Suman Nag, Henry Gong, Lin Qi, Thomas C. Irving

J Gen Physiol (2022) 154 (12): e202213213.

https://doi.org/10.1085/jgp.202213213

Published: 01 November 2022

View article titled, Cardiac myosin filaments are directly regulated by calcium

Includes: Supplementary data

NARROW

Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

How can AI accelerate advances in physiology?

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?

cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca²⁺-handling abnormalities

RLC phosphorylation amplifies Ca²⁺ sensitivity of force in myocardium from cMyBP-C knockout mice

Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging

Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Calcium activation through thick and thin?

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Variants of the myosin interacting-heads motif

Cardiac myosin filaments are directly regulated by calcium

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