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Molecular Physiology
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Journal Articles

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)

John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202513778.
https://doi.org/10.1085/jgp.202513778
Published: 28 April 2025
View articletitled, Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
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Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View articletitled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression

Lucian Medrihan, Margarete G. Knudsen, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa, Paul Greengard, Ana Milosevic
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413693.
https://doi.org/10.1085/jgp.202413693
Published: 07 March 2025
View articletitled, Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression
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Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View articletitled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Inactivation of CaV1 and CaV2 channels

Worawan B. Limpitikul, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202313531.
https://doi.org/10.1085/jgp.202313531
Published: 30 January 2025
View articletitled, Inactivation of CaV1 and CaV2 channels
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Journal Articles

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials

Phil Alexander Köster, Enrico Leipold, Jenny Tigerholm, Anna Maxion, Barbara Namer, Thomas Stiehl, Angelika Lampert
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2025) 157 (2): e202313526.
https://doi.org/10.1085/jgp.202313526
Published: 21 January 2025
View articletitled, Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View articletitled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View articletitled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers

Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413676.
https://doi.org/10.1085/jgp.202413676
Published: 20 December 2024
View articletitled, Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers
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Journal Articles

Intrinsic adaptive plasticity in mouse and human sensory neurons

Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou, Tayler D. Sheahan, Andrew J. Shepherd, Richard A. Slivicki, John A. Lemen, Theodore J. Price, Bryan A. Copits, Robert W. Gereau, IV
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 157 (1): e202313488.
https://doi.org/10.1085/jgp.202313488
Published: 17 December 2024
View articletitled, Intrinsic adaptive plasticity in mouse and human sensory neurons
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Journal Articles

Null method to estimate the maximal PA at subsaturating concentrations of agonist

Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413644.
https://doi.org/10.1085/jgp.202413644
Published: 25 November 2024
View articletitled, Null method to estimate the maximal PA at subsaturating concentrations of agonist
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Journal Articles

Regulation of NMDAR activation efficiency by environmental factors and subunit composition

Miaomiao He, Lonnie P. Wollmuth
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413637.
https://doi.org/10.1085/jgp.202413637
Published: 22 November 2024
View articletitled, Regulation of NMDAR activation efficiency by environmental factors and subunit composition
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Journal Articles

Stable oxidative posttranslational modifications alter the gating properties of RyR1

Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313515.
https://doi.org/10.1085/jgp.202313515
Published: 05 November 2024
View articletitled, Stable oxidative posttranslational modifications alter the gating properties of RyR1
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Includes: Supplementary data
Journal Articles

Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors

Arnaldo Mercado-Perez, Jeric P. Hernandez, Yaroslav Fedyshyn, Anthony J. Treichel, Vikram Joshi, Kimberlee Kossick, Kalpana R. Betageri, Gianrico Farrugia, Brooke Druliner, Arthur Beyder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202213324.
https://doi.org/10.1085/jgp.202213324
Published: 04 November 2024
View articletitled, Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors
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Journal Articles

Mechanism of acid-sensing ion channel modulation by Hi1a

Kyle D. Berger, David M. MacLean
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313519.
https://doi.org/10.1085/jgp.202313519
Published: 24 October 2024
View articletitled, Mechanism of acid-sensing ion channel modulation by Hi1a
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Includes: Supplementary data
Journal Articles

Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina

Olga Chernyshkova, Natalia Erofeeva, Darya Meshalkina, Anna Balykina, Stepan Gambaryan, Michael Belyakov, Michael Firsov
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313530.
https://doi.org/10.1085/jgp.202313530
Published: 22 October 2024
View articletitled, Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina
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Includes: Supplementary data
Journal Articles

Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

Andrew F. Mead, Neil B. Wood, Shane R. Nelson, Bradley M. Palmer, Lin Yang, Samantha Beck Previs, Angela Ploysangngam, Guy G. Kennedy, Jennifer F. McAdow, Sarah M. Tremble, Marcus A. Zimmermann, Marilyn J. Cipolla, Alicia M. Ebert, Aaron N. Johnson, Christina A. Gurnett, Michael J. Previs, David M. Warshaw
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2024) 156 (12): e202413604.
https://doi.org/10.1085/jgp.202413604
Published: 07 October 2024
View articletitled, Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle
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Includes: Supplementary data
Journal Articles

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313502.
https://doi.org/10.1085/jgp.202313502
Published: 20 September 2024
View articletitled, A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
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Journal Articles

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities

Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413600.
https://doi.org/10.1085/jgp.202413600
Published: 20 September 2024
View articletitled, An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities
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Includes: Supplementary data
Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View articletitled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data