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Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction

Noortje W.M. van den Braak, Samuel Kuehs, Greta Z. Peschke, Barbara Namer, Annette Lischka, Katja Eggermann, Christina Dumke, Vishal Sudha Bhagavath Eswaran, Stefan Nikolin, Joachim Weis, Jörg B. Schulz, Angelika Lampert, Ingo Kurth, Roman Rolke, Enrico Leipold, Maike F. Dohrn
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413691.
https://doi.org/10.1085/jgp.202413691
Published: 24 October 2025
View article titled, Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction
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Includes: Supplementary data
Journal Articles

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh D. Plant
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513837.
https://doi.org/10.1085/jgp.202513837
Published: 14 October 2025
View article titled, SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1
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Includes: Supplementary data
Journal Articles

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W. York, Robert C. Tryon, Gretchen A. Meyer, Colin G. Nichols
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513781.
https://doi.org/10.1085/jgp.202513781
Published: 07 October 2025
View article titled, Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice
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Journal Articles

NALCN/Cch1 channelosome subunits originated in early eukaryotes

Adriano Senatore, Tatiana D. Mayorova, Luis A. Yañez-Guerra, Wassim Elkhatib, Brian Bejoy, Philippe Lory, Arnaud Monteil
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2025) 157 (6): e202413636.
https://doi.org/10.1085/jgp.202413636
Published: 05 September 2025
View article titled, NALCN/Cch1 channelosome subunits originated in early eukaryotes
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Includes: Supplementary data
Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413737.
https://doi.org/10.1085/jgp.202413737
Published: 26 August 2025
View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle
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Includes: Supplementary data
Journal Articles

Kinetics of aldosterone-dependent ENaC trafficking in the kidney

Gustavo Frindt, Shujie Shi, Trine Krogh-Madsen, Theresa Rohan, Sarah Christine M. Whelan, Lawrence G. Palmer
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513821.
https://doi.org/10.1085/jgp.202513821
Published: 12 August 2025
View article titled, Kinetics of aldosterone-dependent ENaC trafficking in the kidney
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Includes: Supplementary data
Journal Articles

Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+

Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, David Naranjo
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202413590.
https://doi.org/10.1085/jgp.202413590
Published: 07 August 2025
View article titled, Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+
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Includes: Supplementary data
Journal Articles

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Rebeca Martínez-Lázaro, Teresa Minguez-Viñas, Andrea Reyes-Carrión, Ricardo Gómez, Diego Alvarez de la Rosa, David Bartolomé-Martín, Teresa Giraldez
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513799.
https://doi.org/10.1085/jgp.202513799
Published: 05 August 2025
View article titled, GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains
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Includes: Supplementary data
Journal Articles

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

Martin C. Heiss, Monica L. Fernández-Quintero, Marta Campiglio, Yousra El Ghaleb, Simone Pelizzari, Johannes R. Loeffler, Klaus R. Liedl, Petronel Tuluc, Bernhard E. Flucher
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513769.
https://doi.org/10.1085/jgp.202513769
Published: 04 August 2025
View article titled, Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation
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Includes: Supplementary data
Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)

In Special Collection:
Neuroscience Collection 2025
John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202513778.
https://doi.org/10.1085/jgp.202513778
Published: 28 April 2025
View article titled, Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
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Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View article titled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression

In Special Collection:
Neuroscience Collection 2025
Lucian Medrihan, Margarete G. Knudsen, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa, Paul Greengard, Ana Milosevic
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413693.
https://doi.org/10.1085/jgp.202413693
Published: 07 March 2025
View article titled, Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression
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Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Inactivation of CaV1 and CaV2 channels

Worawan B. Limpitikul, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202313531.
https://doi.org/10.1085/jgp.202313531
Published: 30 January 2025
View article titled, Inactivation of CaV1 and CaV2 channels
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Journal Articles

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials

In Special Collection:
Neuroscience Collection 2025
Phil Alexander Köster, Enrico Leipold, Jenny Tigerholm, Anna Maxion, Barbara Namer, Thomas Stiehl, Angelika Lampert
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2025) 157 (2): e202313526.
https://doi.org/10.1085/jgp.202313526
Published: 21 January 2025
View article titled, Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers

In Special Collection:
JGP Highlights Collection 2025
Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413676.
https://doi.org/10.1085/jgp.202413676
Published: 20 December 2024
View article titled, Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers
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