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Journal Articles

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Philipp A.M. Schmidpeter, Crina M. Nimigean
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614025.
https://doi.org/10.1085/jgp.202614025
Published: 09 July 2026
View article titled, Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels
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Journal Articles

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)

Nicolas Colmano, Daniel Self, Hang N. Nielsen, Rikke Holm, Chai C. Gopalasingam, Ryota Fujimura, Kazuhiro Abe, Bente Vilsen, Sho T. Yano, Pablo Artigas
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513959.
https://doi.org/10.1085/jgp.202513959
Published: 30 June 2026
View article titled, On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)
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Includes: Supplementary data
Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202513945.
https://doi.org/10.1085/jgp.202513945
Published: 28 May 2026
View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58
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Includes: Supplementary data
Journal Articles

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Varun Verma, Ethan S. Lindgren, Marc H. Levin, Onur Cil, Lukmanee Tradtrantip, Rongshan Yan, Neel D. Pasricha, Alan S. Verkman
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (4): e202513958.
https://doi.org/10.1085/jgp.202513958
Published: 22 May 2026
View article titled, Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics
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Journal Articles

Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413734.
https://doi.org/10.1085/jgp.202413734
Published: 24 April 2026
View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation
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Includes: Supplementary data
Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513819.
https://doi.org/10.1085/jgp.202513819
Published: 05 March 2026
View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen
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Journal Articles

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Sarah McGuinness, Pan Li, Ye Li, Shadi Fuladi, Sukanya Konar, Samaneh Sajjadi, Mohammed Sidahmed, Yueying Li, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513824.
https://doi.org/10.1085/jgp.202513824
Published: 12 February 2026
View article titled, Molecular dynamics analyses of CLDN15 pore size and charge selectivity
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Journal Articles

The relationship between apparent potentiation and the magnitude of the control response

Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513894.
https://doi.org/10.1085/jgp.202513894
Published: 27 January 2026
View article titled, The relationship between apparent potentiation and the magnitude of the control response
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Journal Articles

On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513794.
https://doi.org/10.1085/jgp.202513794
Published: 12 December 2025
View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC
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Includes: Supplementary data
Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

Kinetics of aldosterone-dependent ENaC trafficking in the kidney

Gustavo Frindt, Shujie Shi, Trine Krogh-Madsen, Theresa Rohan, Sarah Christine M. Whelan, Lawrence G. Palmer
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513821.
https://doi.org/10.1085/jgp.202513821
Published: 12 August 2025
View article titled, Kinetics of aldosterone-dependent ENaC trafficking in the kidney
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Includes: Supplementary data
Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View article titled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Null method to estimate the maximal PA at subsaturating concentrations of agonist

Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413644.
https://doi.org/10.1085/jgp.202413644
Published: 25 November 2024
View article titled, Null method to estimate the maximal PA at subsaturating concentrations of agonist
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Journal Articles

Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae

Joseph F.S. Davies, Andrew Daab, Nicholas Massouh, Corey Kirkland, Bernadette Strongitharm, Andrew Leech, Marta Farré, Gavin H. Thomas, Christopher Mulligan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202413584.
https://doi.org/10.1085/jgp.202413584
Published: 18 November 2024
View article titled, Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae
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Includes: Supplementary data
Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View article titled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data
Journal Articles

Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism

Olle Rönnelid, Fredrik Elinder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313516.
https://doi.org/10.1085/jgp.202313516
Published: 04 June 2024
View article titled, Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism
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Journal Articles

Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313514.
https://doi.org/10.1085/jgp.202313514
Published: 23 April 2024
View article titled, Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore
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