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Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View article titled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data
Journal Articles

Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism

Olle Rönnelid, Fredrik Elinder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313516.
https://doi.org/10.1085/jgp.202313516
Published: 04 June 2024
View article titled, Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism
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Journal Articles

Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313514.
https://doi.org/10.1085/jgp.202313514
Published: 23 April 2024
View article titled, Mutation in pore-helix modulates interplay between filter gate and Ba<sup>2+</sup> block in a Kcv channel pore
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Journal Articles

Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Anaïs Bertaud, Thierry Cens, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Lisa Soussi, Claudine Ménard, Akelsso Kadala, Claude Collet, Sébastien Dutertre, Patrick Bois, Pascal Gosselin-Badaroudine, Jean-Baptiste Thibaud, Julien Roussel, Michel Vignes, Mohamed Chahine, Pierre Charnet
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313509.
https://doi.org/10.1085/jgp.202313509
Published: 01 April 2024
View article titled, Honeybee Ca<sub>V</sub>4 has distinct permeation, inactivation, and pharmacology from homologous Na<sub>V</sub> channels
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Journal Articles

Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family

In Special Collection:
Molecular Insights into Membrane Protein Function
Rachael M. Lucero, Kemal Demirer, Trevor Justin Yeh, Randy B. Stockbridge
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (3): e202313464.
https://doi.org/10.1085/jgp.202313464
Published: 31 January 2024
View article titled, Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family
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Includes: Supplementary data
Journal Articles

Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes

Tytus Bernas, John Seo, Zachary T. Wilson, Bi-hua Tan, Isabelle Deschenes, Christiane Carter, Jinze Liu, Gea-Ny Tseng
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (2): e202313436.
https://doi.org/10.1085/jgp.202313436
Published: 16 January 2024
View article titled, Persistent PKA activation redistributes Na<sub>V</sub>1.5 to the cell surface of adult rat ventricular myocytes
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Includes: Supplementary data
Journal Articles

Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels

Pedro J. del Rivero Morfin, Audrey L. Kochiss, Klaus R. Liedl, Bernhard E. Flucher, Monica L.I. Fernández-Quintero, Manu Ben-Johny
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (2): e202313365.
https://doi.org/10.1085/jgp.202313365
Published: 04 January 2024
View article titled, Asymmetric contribution of a selectivity filter gate in triggering inactivation of Ca<sub>V</sub>1.3 channels
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Journal Articles

Mechanism of hydrophobic gating in the acetylcholine receptor channel pore

Monika Kumari, Nadira Khatoon, Rachita Sharma, Sushanth Adusumilli, Anthony Auerbach, Hemant K. Kashyap, Tapan K. Nayak
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (2): e202213189.
https://doi.org/10.1085/jgp.202213189
Published: 28 December 2023
View article titled, Mechanism of hydrophobic gating in the acetylcholine receptor channel pore
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Includes: Supplementary data
Journal Articles

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C. Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (2): e202313368.
https://doi.org/10.1085/jgp.202313368
Published: 21 December 2023
View article titled, Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na<sub>V</sub>1.7 channel
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Includes: Supplementary data
Journal Articles

The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

In Special Collection:
Biophysics 2024
Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2023) 155 (11): e202113070.
https://doi.org/10.1085/jgp.202113070
Published: 26 September 2023
View article titled, The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2
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Includes: Supplementary data
Journal Articles

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Denis B. Tikhonov, Boris S. Zhorov
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (11): e202313418.
https://doi.org/10.1085/jgp.202313418
Published: 20 September 2023
View article titled, Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels
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Journal Articles

ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle

Elizabeth J. Akin, Joydeep Aoun, Connor Jimenez, Katie Mayne, Julius Baeck, Michael D. Young, Brennan Sullivan, Kenton M. Sanders, Sean M. Ward, Simon Bulley, Jonathan H. Jaggar, Scott Earley, Iain A. Greenwood, Normand Leblanc
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (11): e202213217.
https://doi.org/10.1085/jgp.202213217
Published: 13 September 2023
View article titled, ANO1, Ca<sub>V</sub>1.2, and IP<sub>3</sub>R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle
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Includes: Supplementary data
Journal Articles

The physical basis of osmosis

Gerald S. Manning, Alan R. Kay
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (10): e202313332.
https://doi.org/10.1085/jgp.202313332
Published: 25 August 2023
View article titled, The physical basis of osmosis
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Journal Articles

Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents

In Special Collection:
Neuroscience Collection 2023 , Physiology of Pain Detection and Processing Collection 2023
Sophia Kriegeskorte, Raya Bott, Martin Hampl, Alon Korngreen, Ralf Hausmann, Angelika Lampert
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (9): e202213312.
https://doi.org/10.1085/jgp.202213312
Published: 02 August 2023
View article titled, Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents
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Includes: Supplementary data
Journal Articles

Urea transport in human red blood cells: Donor variation compared to chloride, glucose, and water transport

Jonas Leifelt, Morten Hanefeld Dziegiel, Jesper Brahm
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (10): e202213321.
https://doi.org/10.1085/jgp.202213321
Published: 02 August 2023
View article titled, Urea transport in human red blood cells: Donor variation compared to chloride, glucose, and water transport
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Journal Articles

EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods

Wallace B. Thoreson, Bhavana Chhunchha
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (9): e202313349.
https://doi.org/10.1085/jgp.202313349
Published: 21 July 2023
View article titled, EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods
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Journal Articles

Patch-clamp technique to study mitochondrial membrane biophysics

In Special Collection:
Physiology of Pain Detection and Processing Collection 2023
Anshu Kumari, Dung M. Nguyen, Vivek Garg
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (8): e202313347.
https://doi.org/10.1085/jgp.202313347
Published: 22 June 2023
View article titled, Patch-clamp technique to study mitochondrial membrane biophysics
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Journal Articles

Interactions between selectivity filter and pore helix control filter gating in the MthK channel

Wojciech Kopec, Andrew S. Thomson, Bert L. de Groot, Brad S. Rothberg
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (8): e202213166.
https://doi.org/10.1085/jgp.202213166
Published: 15 June 2023
View article titled, Interactions between selectivity filter and pore helix control filter gating in the MthK channel
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Journal Articles

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

Elissa Moller, Madolyn Britt, Anthony Schams, Hannah Cetuk, Andriy Anishkin, Sergei Sukharev
Journal: Journal of General Physiology
Series: Mechanotransduction by Membrane Proteins
J Gen Physiol (2023) 155 (5): e202213168.
https://doi.org/10.1085/jgp.202213168
Published: 06 April 2023
View article titled, Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response
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Includes: Supplementary data
Journal Articles

Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors

Paweorn Angsutararux, Amal K. Dutta, Martina Marras, Carlota Abella, Rebecca L. Mellor, Jingyi Shi, Jeanne M. Nerbonne, Jonathan R. Silva
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202213300.
https://doi.org/10.1085/jgp.202213300
Published: 21 March 2023
View article titled, Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors
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Includes: Supplementary data