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Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae

J Gen Physiol (2025) 157 (3): e202313506.

https://doi.org/10.1085/jgp.202313506

Published: 21 February 2025

View articletitled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Includes: Supplementary data

Journal Articles

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

In Special Collection:

Molecular Insights into Membrane Protein Function

Vamseedhar Rayaprolu, Heini M. Miettinen, William D. Baker, Victoria C. Young, Matthew Fisher, Gwendolyn Mueller, William O. Rankin, John T. Kelley, William J. Ratzan, Lee Min Leong, Joshua A. Davisson, Bradley J. Baker, Susy C. Kohout

J Gen Physiol (2024) 156 (7): e202313467.

https://doi.org/10.1085/jgp.202313467

Published: 21 May 2024

View articletitled, Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

Includes: Supplementary data

Journal Articles

The physical basis of osmosis

Gerald S. Manning, Alan R. Kay

J Gen Physiol (2023) 155 (10): e202313332.

https://doi.org/10.1085/jgp.202313332

Published: 25 August 2023

View articletitled, The physical basis of osmosis

Journal Articles

Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

Thasin A. Peyear, Olaf S. Andersen

J Gen Physiol (2023) 155 (4): e202213247.

https://doi.org/10.1085/jgp.202213247

Published: 10 February 2023

View articletitled, Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

Includes: Supplementary data

Journal Articles

Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

In Special Collection:

Neuroscience Collection 2023

Miriam B. Goodman, Elizabeth S. Haswell, Valeria Vásquez

J Gen Physiol (2023) 155 (3): e202213248.

https://doi.org/10.1085/jgp.202213248

Published: 25 January 2023

View articletitled, Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

Journal Articles

Gating and modulation of an inward-rectifier potassium channel

In Special Collection:

Biophysics 2023

Vishwanath Jogini, Morten Ø. Jensen, David E. Shaw

J Gen Physiol (2022) 155 (2): e202213085.

https://doi.org/10.1085/jgp.202213085

Published: 16 December 2022

View articletitled, Gating and modulation of an inward-rectifier potassium channel

Includes: Supplementary data

Journal Articles

Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development

In Special Collection:

Neuroscience Collection 2023

Jamison L. Nourse, Vivian M. Leung, Hamid Abuwarda, Elizabeth L. Evans, Esmeralda Izquierdo-Ortiz, Alan T. Ly, Nguyen Truong, Samantha Smith, Harsh Bhavsar, Gabriella Bertaccini, Edwin S. Monuki, Mitradas M. Panicker, Medha M. Pathak

J Gen Physiol (2022) 154 (10): e202213084.

https://doi.org/10.1085/jgp.202213084

Published: 07 September 2022

View articletitled, Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development

Includes: Supplementary data

Journal Articles

Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells

Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille

J Gen Physiol (2022) 154 (6): e202113074.

https://doi.org/10.1085/jgp.202113074

Published: 18 May 2022

View articletitled, Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells

Journal Articles

Structural determinants of acid-sensing ion channel potentiation by single chain lipids

In Special Collection:

Biophysics 2023

Robert C. Klipp, John R. Bankston

J Gen Physiol (2022) 154 (7): e202213156.

https://doi.org/10.1085/jgp.202213156

Published: 18 May 2022

View articletitled, Structural determinants of acid-sensing ion channel potentiation by single chain lipids

Includes: Supplementary data

Journal Articles

Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1

In Special Collection:

Neuroscience Collection 2022

Gucan Dai

J Gen Physiol (2022) 154 (4): e202112888.

https://doi.org/10.1085/jgp.202112888

Published: 23 February 2022

View articletitled, Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1

Journal Articles

Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P₂ synthesis

Lizbeth de la Cruz, Christopher Kushmerick, Jane M. Sullivan, Martin Kruse, Oscar Vivas

J Gen Physiol (2022) 154 (3): e202113001.

https://doi.org/10.1085/jgp.202113001

Published: 18 February 2022

View articletitled, Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis

Includes: Supplementary data

Journal Articles

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity

In Special Collection:

Biophysics 2022

Mohammad-Reza Ghovanloo, Koushik Choudhury, Tagore S. Bandaru, Mohamed A. Fouda, Kaveh Rayani, Radda Rusinova, Tejas Phaterpekar, Karen Nelkenbrecher, Abeline R. Watkins, Damon Poburko, Jenifer Thewalt, Olaf S. Andersen, Lucie Delemotte, Samuel J. Goodchild, Peter C. Ruben

J Gen Physiol (2021) 153 (5): e202012701.

https://doi.org/10.1085/jgp.202012701

Published: 09 April 2021

View articletitled, Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity

Includes: Supplementary data

Journal Articles

Distinct lipid bilayer compositions have general and protein-specific effects on K⁺ channel function

In Special Collection:

Ion Channels Update 2022

Laura-Marie Winterstein, Kerri Kukovetz, Ulf-Peter Hansen, Indra Schroeder, James L. Van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh

J Gen Physiol (2021) 153 (2): e202012731.

https://doi.org/10.1085/jgp.202012731

Published: 13 January 2021

View articletitled, Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function

Journal Articles

A method for imaging single molecules at the plasma membrane of live cells within tissue slices

Gregory I. Mashanov, Tatiana A. Nenasheva, Tatiana Mashanova, Catherine Maclachlan, Nigel J.M. Birdsall, Justin E. Molloy

J Gen Physiol (2020) 153 (1): e202012657.

https://doi.org/10.1085/jgp.202012657

Published: 16 December 2020

View articletitled, A method for imaging single molecules at the plasma membrane of live cells within tissue slices

Journal Articles

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation

Jongyun Myeong, Lizbeth de la Cruz, Seung-Ryoung Jung, Jun-Hee Yeon, Byung-Chang Suh, Duk-Su Koh, Bertil Hille

J Gen Physiol (2020) 152 (12): e202012627.

https://doi.org/10.1085/jgp.202012627

Published: 13 November 2020

View articletitled, Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation

Includes: Supplementary data

Journal Articles

ATP synthase: Evolution, energetics, and membrane interactions

Jasmine A. Nirody, Itay Budin, Padmini Rangamani

J Gen Physiol (2020) 152 (11): e201912475.

https://doi.org/10.1085/jgp.201912475

Published: 23 September 2020

View articletitled, ATP synthase: Evolution, energetics, and membrane interactions

Journal Articles

Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters

Pietro Ridone, Elvis Pandzic, Massimo Vassalli, Charles D. Cox, Alexander Macmillan, Philip A. Gottlieb, Boris Martinac

J Gen Physiol (2020) 152 (8): e201912515.

https://doi.org/10.1085/jgp.201912515

Published: 24 June 2020

View articletitled, Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters

Journal Articles

A novel theoretical framework reveals more than one voltage-sensing pathway in the lateral membrane of outer hair cells

Brenda Farrell, Benjamin L. Skidmore, Vivek Rajasekharan, William E. Brownell

J Gen Physiol (2020) 152 (7): e201912447.

https://doi.org/10.1085/jgp.201912447

Published: 08 May 2020

View articletitled, A novel theoretical framework reveals more than one voltage-sensing pathway in the lateral membrane of outer hair cells

Includes: Supplementary data

Journal Articles

Engineering an enhanced voltage-sensing phosphatase

Akira Kawanabe, Natsuki Mizutani, Onur K. Polat, Tomoko Yonezawa, Takafumi Kawai, Masayuki X. Mori, Yasushi Okamura

J Gen Physiol (2020) 152 (5): e201912491.

https://doi.org/10.1085/jgp.201912491

Published: 13 March 2020

View articletitled, Engineering an enhanced voltage-sensing phosphatase

Journal Articles

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Grigory Maksaev, Harald Bernsteiner, Feifei Ren, Peng Yuan, Anna Stary-Weinzinger, Colin G. Nichols

J Gen Physiol (2019) 152 (1): e201912422.

https://doi.org/10.1085/jgp.201912422

Published: 19 November 2019

View articletitled, Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

Includes: Supplementary data

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Date

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

The physical basis of osmosis

Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

Gating and modulation of an inward-rectifier potassium channel

Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development

Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells

Structural determinants of acid-sensing ion channel potentiation by single chain lipids

Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1

Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P₂ synthesis

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity

Distinct lipid bilayer compositions have general and protein-specific effects on K⁺ channel function

A method for imaging single molecules at the plasma membrane of live cells within tissue slices

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation

ATP synthase: Evolution, energetics, and membrane interactions

Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters

A novel theoretical framework reveals more than one voltage-sensing pathway in the lateral membrane of outer hair cells

Engineering an enhanced voltage-sensing phosphatase

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

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