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Journal Articles
The Journal of General Physiology (2020) 152 (2): e201912501.
Published: 14 January 2020
Includes: Supplementary data
Journal Articles
The Journal of General Physiology (2020) 152 (2): e201912557.
Published: 10 January 2020
Images
Briana Bohannon (left), Peter Larsson (center), and colleagues reveal that ...
Published: 10 January 2020
Briana Bohannon (left), Peter Larsson (center), and colleagues reveal that PUFAs with distinct head groups can differentially activate the cardiac I Ks channels that terminate ventricular action potentials, raising the prospect of personalized treatments for LQTS. The graph (right) shows that, comp... More
Journal Articles
The Journal of General Physiology (2019) 152 (1): e201912455.
Published: 24 December 2019
Includes: Supplementary data
Images
Three Na transporters play key roles in cardiac physiology and pathology, N...
Published: 24 December 2019
Figure 1. Three Na transporters play key roles in cardiac physiology and pathology, Na/K pumps, Na/Ca exchangers, and NHEs. All three appear to be importantly regulated by inactivation reactions that depend on ion binding to transport sites, Na in the case of Na/Ca exchangers and Na/K pumps and ... More
Images
Ion transport cycle and inactivation reactions of the cardiac (NCX1) Na/Ca ...
Published: 24 December 2019
Figure 2. Ion transport cycle and inactivation reactions of the cardiac (NCX1) Na/Ca exchanger. The transport cycle (states 1 to 4) moves one Ca outwardly and three Na ions inwardly. Inactivation occurs preferentially when three Na are bound to the inwardly facing transport sites and anionic pho... More
Images
Simulation of the two parallel NCX1 inactivation reactions revealed in stud...
Published: 24 December 2019
Figure 3. Simulation of the two parallel NCX1 inactivation reactions revealed in studies of cardiac giant membrane patches. (A) Exchange currents recorded after step changes of cytoplasmic Na and Ca. From left to right: (1) When exchange current is activated by a step increase of cytoplasmic Na... More
Images
Post–Abers Na/K pump cycle with suggested inactivation reactions.  When thr...
Published: 24 December 2019
Figure 4. Post–Abers Na/K pump cycle with suggested inactivation reactions. When three Na are bound to pumps with inwardly facing binding sites (E 1 , state 1), pumps phosphorylate themselves and occlude Na (state 2), followed by opening to the outside (E 2 , state 3), release of Na and binding ... More
Images
Na/K pump currents in a mouse myocyte, recorded as described previously (  ...
Published: 24 December 2019
Figure 5. Na/K pump currents in a mouse myocyte, recorded as described previously ( Lu et al., 2016 ). (A) Whole-cell recording of pump current with 20 mM cytoplasmic Na and 7 mM extracellular Na. (B) Pump current is activated six times by application of 7 mM K for 12 s in exchange for 7 ... More
Images
Rapid pipette perfusion (   Hilgemann and Lu, 1998   ) to determine the tim...
Published: 24 December 2019
Figure 6. Rapid pipette perfusion ( Hilgemann and Lu, 1998 ) to determine the time course of cytoplasmic Na exchange with the pipette tip. Experimental conditions were as described previously ( Lu and Hilgemann, 2017 ), and myocytes were made permeable to monovalent cations with veratridine ... More
Images
Simulation of Na/K pump function in an intact cell with and without inactiv...
Published: 24 December 2019
Figure 7. Simulation of Na/K pump function in an intact cell with and without inactivation that generates a pump reserve three times larger than the active pump pool with 7 mM cytoplasmic Na. (A) Simulated cytoplasmic Na changes with and without inactivation. As indicated, a background Na curre... More
Images
NHE1 Na/H exchange cycle with inactivation.  The exchange cycle moves one N...
Published: 24 December 2019
Figure 8. NHE1 Na/H exchange cycle with inactivation. The exchange cycle moves one Na inwardly and one proton outwardly (states 1 to 4) when the exchanger inactivation domain is disengaged and has three protons occluded within it. Exchangers transition to inactivated states with release of regul... More
Images
Simulations of NHE1 Na/H exchange function using the model described in   F...
Published: 24 December 2019
Figure 9. Simulations of NHE1 Na/H exchange function using the model described in Fig. 8 . Data from the cited papers was extracted digitally and fits were generated as described in the supplemental material. (A) Depletion of ATP is assumed to deplete anionic lipids that maintain NHE1 in a... More
Journal Articles
The Journal of General Physiology (2019) 152 (1): e201912538.
Published: 19 December 2019
Journal Articles
The Journal of General Physiology (2019) 152 (2): e201912396.
Published: 19 December 2019
Includes: Supplementary data
Journal Articles
The Journal of General Physiology (2019) 152 (2): e201912434.
Published: 19 December 2019
Includes: Supplementary data
Images
Putative interaction site between CTD and III-IV linker.  (A)  Schematic of...
Published: 19 December 2019
Figure 1. Putative interaction site between CTD and III-IV linker. (A) Schematic of a VGSC displaying the location of the amino acids involved in the putative interaction site (numbering per Na V 1.5). VSD refers to voltage sensor domain. (B) Structure of Na V Pas (PDB accession no. 5X0M ) a... More
Images
FGF12B and FGF13B, but not CaM, are effective in rescuing persistent curren...
Published: 19 December 2019
Figure 2. FGF12B and FGF13B, but not CaM, are effective in rescuing persistent current in the Δ1885 mutant Na V 1.5 channels. (A) Structure of the Na V 1.5 CTD overlaid on Na V Pas, with a zoomed-in view of the CTD (sky blue) along with CaM (red) and FGF13 (beige). The truncated protein in the ... More
Images
Mutations at the putative interaction site lead to an increased persistent ...
Published: 19 December 2019
Figure 3. Mutations at the putative interaction site lead to an increased persistent current. (A and C) Exemplar traces displaying the persistent currents in WT and mutant VGSCs. (B and D) Quantified data of persistent currents from WT and mutant VGSCs. Gray column with black outline in D repr... More
Images
Mutations at the putative interaction site lead to hyperpolarized shift in ...
Published: 19 December 2019
Figure 4. Mutations at the putative interaction site lead to hyperpolarized shift in steady-state inactivation. (A and C) Steady-state inactivation curves from WT and mutant channels. (B and D) Quantified data of V 1/2 of inactivation from WT and mutant channels. Gray column with black outlin... More