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Journal Articles

A reconstituted depolarization-induced Ca²⁺ release platform for validation of skeletal muscle disease mutations and drug discovery

Takashi Murayama, Nagomi Kurebayashi, Takuro Numaga-Tomita, Takuya Kobayashi, Satoru Okazaki, Kyosuke Yamashiro, Tsutomu Nakada, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, Mitsuhiko Yamada, Takashi Sakurai

J Gen Physiol (2022) 154 (12): e202213230.

DOI: https://doi.org/10.1085/jgp.202213230

Published: 01 November 2022

View article titled, A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery

Includes: Supplementary data

Journal Articles

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca²⁺ dynamics in primary skeletal myocytes

Yoshitaka Tsuboi, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Takashi Murayama, Nagomi Kurebayashi, Toshiaki Tachibana, Yoshinobu Manome, Emi Kikuchi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, Madoka Suzuki, Norio Fukuda, Toshiko Yamazawa

J Gen Physiol (2022) 154 (11): e202213136.

DOI: https://doi.org/10.1085/jgp.202213136

Published: 06 October 2022

View article titled, Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes

Journal Articles

Cytosolic Ca²⁺-dependent Ca²⁺ release activity primarily determines the ER Ca²⁺ level in cells expressing the CPVT-linked mutant RYR2

In Special Collection:

Biophysics 2023

Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, Takashi Sakurai

J Gen Physiol (2022) 154 (9): e202112869.

DOI: https://doi.org/10.1085/jgp.202112869

Published: 21 April 2022

View article titled, Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2

Includes: Supplementary data

Journal Articles

Insights into channel modulation mechanism of RYR1 mutants using Ca²⁺ imaging and molecular dynamics

Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Katsuji Oguchi, Takashi Sakurai, Masamitsu Iino

J Gen Physiol (2019) 152 (1): e201812235.

DOI: https://doi.org/10.1085/jgp.201812235

Published: 16 December 2019

View article titled, Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics

Includes: Supplementary data

Journal Articles

Extensive Ca²⁺ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca²⁺ hypersensitivity

In Special Collection:

Cardiovascular Physiology 2018

Akira Uehara, Takashi Murayama, Midori Yasukochi, Michael Fill, Minoru Horie, Toru Okamoto, Yoshiharu Matsuura, Kiyoko Uehara, Takahiro Fujimoto, Takashi Sakurai, Nagomi Kurebayashi

J Gen Physiol (2017) 149 (2): 199–218.

DOI: https://doi.org/10.1085/jgp.201611624

Published: 12 January 2017

View article titled, Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity

Includes: Supplementary data

NARROW

A reconstituted depolarization-induced Ca²⁺ release platform for validation of skeletal muscle disease mutations and drug discovery

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca²⁺ dynamics in primary skeletal myocytes

Cytosolic Ca²⁺-dependent Ca²⁺ release activity primarily determines the ER Ca²⁺ level in cells expressing the CPVT-linked mutant RYR2

Insights into channel modulation mechanism of RYR1 mutants using Ca²⁺ imaging and molecular dynamics

Extensive Ca²⁺ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca²⁺ hypersensitivity

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A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes

Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics

Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity

Email alerts

This Feature Is Available To Subscribers Only

A reconstituted depolarization-induced Ca²⁺ release platform for validation of skeletal muscle disease mutations and drug discovery

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca²⁺ dynamics in primary skeletal myocytes

Cytosolic Ca²⁺-dependent Ca²⁺ release activity primarily determines the ER Ca²⁺ level in cells expressing the CPVT-linked mutant RYR2

Insights into channel modulation mechanism of RYR1 mutants using Ca²⁺ imaging and molecular dynamics

Extensive Ca²⁺ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca²⁺ hypersensitivity