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Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513877.
https://doi.org/10.1085/jgp.202513877
Published: 17 December 2025
View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?
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Journal Articles

Using neural networks for image analysis in general physiology

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202413623.
https://doi.org/10.1085/jgp.202413623
Published: 17 September 2024
View article titled, Using neural networks for image analysis in general physiology
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Journal Articles

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202413595.
https://doi.org/10.1085/jgp.202413595
Published: 09 July 2024
View article titled, Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue
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Includes: Supplementary data
Journal Articles

Excitation–contraction coupling in cardiac, skeletal, and smooth muscle

Robert T. Dirksen, David A. Eisner, Eduardo Ríos, Karin R. Sipido
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 154 (9): e202213244.
https://doi.org/10.1085/jgp.202213244
Published: 19 August 2022
View article titled, Excitation–contraction coupling in cardiac, skeletal, and smooth muscle
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Includes: Supplementary data
Journal Articles

A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes

Carlo Manno, Eshwar Tammineni, Lourdes Figueroa, Yuriana Oropeza-Almazán, Eduardo Rios
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 154 (9): e202213143.
https://doi.org/10.1085/jgp.202213143
Published: 07 July 2022
View article titled, A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes
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Journal Articles

Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

Eshwar R. Tammineni, Lourdes Figueroa, Natalia Kraeva, Carlo Manno, Carlos A. Ibarra, Amira Klip, Sheila Riazi, Eduardo Rios
Journal: Journal of General Physiology
Series: E–C Coupling Meeting 2021
J Gen Physiol (2021) 154 (9): e2021ecc32.
https://doi.org/10.1085/jgp.2021ecc32
Published: 12 November 2021
View article titled, Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Journal Articles

The binding interactions that maintain excitation–contraction coupling junctions in skeletal muscle

Eduardo Ríos, Dirk Gillespie, Clara Franzini-Armstrong
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (4): 593–605.
https://doi.org/10.1085/jgp.201812268
Published: 06 February 2019
View article titled, The binding interactions that maintain excitation–contraction coupling junctions in skeletal muscle
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Includes: Supplementary data
Journal Articles

Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus

In Special Collection:
Celebrating 100 years of JGP
Eduardo Ríos
Journal: Journal of General Physiology
Series: JGP 100th Anniversary
J Gen Physiol (2018) 150 (4): 521–537.
https://doi.org/10.1085/jgp.201711959
Published: 07 March 2018
View article titled, Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus
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Journal Articles

The voltage sensor of excitation–contraction coupling in mammals: Inactivation and interaction with Ca2+

In Special Collection:
Ion Channel Structure & Function 2018
Juan Ferreira Gregorio, Germán Pequera, Carlo Manno, Eduardo Ríos, Gustavo Brum
Journal: Journal of General Physiology
J Gen Physiol (2017) 149 (11): 1041–1058.
https://doi.org/10.1085/jgp.201611725
Published: 11 October 2017
View article titled, The voltage sensor of excitation–contraction coupling in mammals: Inactivation and interaction with Ca2+
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Journal Articles

Perspectives on “Control of Ca release from within the cardiac sarcoplasmic reticulum”

In Special Collection:
Cardiovascular Physiology 2018
Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2017) 149 (9): 833–836.
https://doi.org/10.1085/jgp.201711847
Published: 10 August 2017
View article titled, Perspectives on “Control of Ca release from within the cardiac sarcoplasmic reticulum”
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Journal Articles

The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle

Eduardo Ríos, Lourdes Figueroa, Carlo Manno, Natalia Kraeva, Sheila Riazi
Journal: Journal of General Physiology
J Gen Physiol (2015) 145 (6): 459–474.
https://doi.org/10.1085/jgp.201411321
Published: 25 May 2015
View article titled, The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle
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Journal Articles

A better method to measure total calcium in biological samples yields immediate payoffs

Carlo Manno, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2015) 145 (3): 167–171.
https://doi.org/10.1085/jgp.201511370
Published: 23 February 2015
View article titled, A better method to measure total calcium in biological samples yields immediate payoffs
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Journal Articles

Life and death of a cardiac calcium spark

Michael D. Stern, Eduardo Ríos, Victor A. Maltsev
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (4): 477.
https://doi.org/10.1085/jgp.20131103409202013c
Published: 30 September 2013
View article titled, Life and death of a cardiac calcium spark
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Journal Articles

Life and death of a cardiac calcium spark

Michael D. Stern, Eduardo Ríos, Victor A. Maltsev
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (3): 257–274.
https://doi.org/10.1085/jgp.201311034
Published: 26 August 2013
View article titled, Life and death of a cardiac calcium spark
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Includes: Supplementary data
Journal Articles

Confocal imaging of transmembrane voltage by SEER of di-8-ANEPPS

Carlo Manno, Lourdes Figueroa, Robert Fitts, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2013) 141 (3): 371–387.
https://doi.org/10.1085/jgp.201210936
Published: 25 February 2013
View article titled, Confocal imaging of transmembrane voltage by SEER of di-8-ANEPPS
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Includes: Multimedia, Supplementary data
Journal Articles

Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle

Vyacheslav M. Shkryl, Lothar A. Blatter, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2012) 139 (3): 189–207.
https://doi.org/10.1085/jgp.201110709
Published: 13 February 2012
View article titled, Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle
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Journal Articles

D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle

Monika Sztretye, Jianxun Yi, Lourdes Figueroa, Jingsong Zhou, Leandro Royer, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2011) 138 (2): 211–229.
https://doi.org/10.1085/jgp.201010591
Published: 25 July 2011
View article titled, D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle
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Includes: Supplementary data
Journal Articles

Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca2+ release in skeletal muscle

Monika Sztretye, Jianxun Yi, Lourdes Figueroa, Jingsong Zhou, Leandro Royer, Paul Allen, Gustavo Brum, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2011) 138 (2): 231–247.
https://doi.org/10.1085/jgp.201010592
Published: 25 July 2011
View article titled, Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca2+ release in skeletal muscle
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Includes: Supplementary data
Journal Articles

Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle

Leandro Royer, Monika Sztretye, Carlo Manno, Sandrine Pouvreau, Jingsong Zhou, Bjorn C. Knollmann, Feliciano Protasi, Paul D. Allen, Eduardo Ríos
Journal: Journal of General Physiology
J Gen Physiol (2010) 136 (3): 325–338.
https://doi.org/10.1085/jgp.201010454
Published: 16 August 2010
View article titled, Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle
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Includes: Supplementary data
Journal Articles

Calcium Release Flux Underlying Ca2+ Sparks of Frog Skeletal Muscle

Eduardo Ríos, Michael D. Stern, Adom González, Gonzalo Pizarro, Natalia Shirokova
Journal: Journal of General Physiology
J Gen Physiol (1999) 114 (1): 31–48.
https://doi.org/10.1085/jgp.114.1.31
Published: 01 July 1999
View article titled, Calcium Release Flux Underlying Ca2+ Sparks of Frog Skeletal Muscle
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