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Christopher J. Lingle
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Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613985.
https://doi.org/10.1085/jgp.202613985
Published: 22 May 2026
View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents
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Includes: Supplementary data
Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells

In Special Collection:
Neuroscience Collection 2021
Pedro L. Martinez-Espinosa, Chengtao Yang, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (4): e202012785.
https://doi.org/10.1085/jgp.202012785
Published: 02 March 2021
View article titled, Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells
Open the PDF for Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells in another window
Journal Articles

Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways

In Special Collection:
Neuroscience Collection 2021
Pedro L. Martinez-Espinosa, Alan Neely, Jiuping Ding, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (4): e202012784.
https://doi.org/10.1085/jgp.202012784
Published: 01 March 2021
View article titled, Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways
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Journal Articles

Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel

In Special Collection:
Ion Channel Structure & Function 2018 , JGP Reviews: Ion Channel Structure and Function
Yu Zhou, Huanghe Yang, Jianmin Cui, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2017) 149 (11): 985–1007.
https://doi.org/10.1085/jgp.201711845
Published: 12 October 2017
View article titled, Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel
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Includes: Supplementary data
Journal Articles

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism

Yu Zhou, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2014) 144 (5): 415–440.
https://doi.org/10.1085/jgp.201411259
Published: 27 October 2014
View article titled, Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
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Journal Articles

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity

Pedro L. Martinez-Espinosa, Chengtao Yang, Vivian Gonzalez-Perez, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2014) 144 (4): 275–295.
https://doi.org/10.1085/jgp.201411253
Published: 29 September 2014
View article titled, Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
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Includes: Supplementary data
Journal Articles

Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

Xu-Hui Zeng, Betsy Navarro, Xiao-Ming Xia, David E. Clapham, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (3): 305–313.
https://doi.org/10.1085/jgp.201311011
Published: 26 August 2013
View article titled, Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
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Journal Articles

Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix

Yu Zhou, Qiong-Yao Tang, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2010) 135 (5): 481–494.
https://doi.org/10.1085/jgp.201010403
Published: 26 April 2010
View article titled, Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
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Journal Articles

Closed-channel block of BK potassium channels by bbTBA requires partial activation

Qiong-Yao Tang, Xu-Hui Zeng, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2009) 134 (5): 409–436.
https://doi.org/10.1085/jgp.200910251
Published: 26 October 2009
View article titled, Closed-channel block of BK potassium channels by bbTBA requires partial activation
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Includes: Supplementary data
Journal Articles

N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels

Zhe Zhang, Xu-Hui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2009) 133 (3): 263–282.
https://doi.org/10.1085/jgp.200810079
Published: 23 February 2009
View article titled, N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels
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Includes: Supplementary data
Journal Articles

Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits

Xuhui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2008) 132 (1): 115–129.
https://doi.org/10.1085/jgp.200809969
Published: 30 June 2008
View article titled, Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits
Open the PDF for Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits in another window
Includes: Supplementary data
Journal Articles

Mg2+-dependent Regulation of BK Channels: Importance of Electrostatics

Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2007) 131 (1): 5–11.
https://doi.org/10.1085/jgp.200709937
Published: 31 December 2007
View article titled, Mg2+-dependent Regulation of BK Channels: Importance of Electrostatics
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Journal Articles

Gating Rings Formed by RCK Domains: Keys to Gate Opening

Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2007) 129 (2): 101–107.
https://doi.org/10.1085/jgp.200709739
Published: 29 January 2007
View article titled, Gating Rings Formed by RCK Domains: Keys to Gate Opening
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Journal Articles

pH-regulated Slo3 K+ Channels: Properties of Unitary Currents

Xue Zhang, Xuhui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (3): 301–315.
https://doi.org/10.1085/jgp.200609551
Published: 28 August 2006
View article titled, pH-regulated Slo3 K+ Channels: Properties of Unitary Currents
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Journal Articles

Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents

Xue Zhang, Xuhui Zeng, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (3): 317–336.
https://doi.org/10.1085/jgp.200609552
Published: 28 August 2006
View article titled, Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents
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Journal Articles

Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits

G. Richard Benzinger, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 127 (2): 119–131.
https://doi.org/10.1085/jgp.200509425
Published: 17 January 2006
View article titled, Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits
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Journal Articles

Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites

Xu-Hui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2005) 125 (3): 273–286.
https://doi.org/10.1085/jgp.200409239
Published: 28 February 2005
View article titled, Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites
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Journal Articles

Inactivation of BK Channels by the NH2 Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues

Xiao-Ming Xia, J.P. Ding, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2003) 121 (2): 125–148.
https://doi.org/10.1085/jgp.20028667
Published: 03 February 2003
View article titled, Inactivation of BK Channels by the NH2 Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues
Open the PDF for Inactivation of BK Channels by the NH2 Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues in another window

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