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JGP study shows that a mutation linked to dilated cardiomyopathy stabilizes β-cardiac myosin in its autoinhibited, super-relaxed state.

Viewpoint

In this Viewpoint, Holt, Fettiplace, and Müller weigh the evidence supporting a role for PIEZO and TMC channels in mechanosensory transduction in inner ear hair cells.

Articles

Duno-Miranda et al. investigate the E525K mutation in human β-cardiac myosin, a protein crucial for heart contraction, and its role in causing dilated cardiomyopathy (DCM). They demonstrate that the length of the myosin tail influences its self-inhibition and that the E525K mutation strengthens this effect, potentially reducing heart contractility in DCM.

HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page and Ruben find that cannabidiol potentiates HCN4 channels independently of other activators (cAMP) and agonists (PIP2) via binding to a lipid-binding pocket at the C-terminus of the voltage sensor.

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