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In Special Collection:
Research News Collection 2020

JGP study reveals that low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state unable to bind actin.

Reviews

Rudnick and Sandtner review the history of serotonin transporter research in light of structural and electrophysiological advances.

Viewpoint

Evidence on two- and three-state models of the calcium regulation models of muscle contractions remain in favor of three-state models.

Research Articles

The active force of mammalian skeletal muscle is reduced at low temperatures. Caremani et al. reveal that this is due to the rise of a population of myosin motors captured in a refractory state insensitive to muscle activation.

This paper describes the first extensive study of voltage-clamp recordings from WT and mutant mouse cone photoreceptors made from dark-adapted retinas without fluorescent markers. Cones can continue to adapt rapidly in bright light, even without known mechanisms of transduction modulation.

Purkinje neurons express voltage-gated Na channels and auxiliary proteins that facilitate rapid firing. White et al. find that Na current in isolated Purkinje cells is unaffected by loss of NaVβ4 subunits, but transient current is briefer and resurgent current is reduced without the FGF14 protein.

Methods and Approaches

Meyer et al. establish the suitability of the sodium-sensitive indicator dye CoroNaGreen for fluorescence lifetime imaging inside cells. This approach represents a valuable tool for quantitative and dynamic determination of intracellular sodium concentrations independent of dye concentration.

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