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Cover Image
Cover Image
Cover picture: Morphology of control and myosin-binding protein C (MyBPC) morphant 4–d postfertilization zebrafish larvae. Injections were performed with morpholino antisense oligonucleotides with a control sequence (top left, bottom left) and sequences blocking the slow skeletal isoform (MyBPC-1, top right) and the two fast skeletal isoforms MyBPC-2A (middle left) and MyBPC-2B (middle right, bottom right). The MyBPC-2B morphant exhibits a pathological phenotype with shorter larval length and disorganized muscle fibers (see Research Article by Li et al., 309–322).
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Review
Article
Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy
MyBPC: A muscle protein for all seasons.
Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling
As the urinary bladder fills, the rate of rise (but not the frequency) of spontaneous contractions of smooth muscle in the bladder wall increases, thereby eliciting increased afferent nerve activity that signals the fullness of the bladder.
The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit
Researchers identify regions of tissue-specific γ subunits that are responsible for regulating the activity of calcium-activated potassium channels.
Methods and Approaches
Stabilization of a prokaryotic LAT transporter by random mutagenesis
A fluorescence-based screen was used to analyze 70 LAT transporter mutants and identify variants with improved stability and monodispersity.
