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We are pleased to welcome several new JGP Associate Editors and Editorial Advisory Board members.

Generally Physiological


Nav1.5 channels bearing voltage-sensor domain mutations associated with atypical cardiac arrhythmias and dilated cardiomyopathy generate gating pore currents.

Cysteine substitution accessibility analysis suggests that the TH6–TH7 segment forms a constriction in the diphtheria toxin T-domain channel.

Methods and Approaches

The concentration of total calcium in a skeletal muscle appears to be correlated with the muscle’s likely force requirements given by the ratio of body weight to muscle weight.


The isolated Nav channel domain IV paddle motif remains susceptible to toxins that inhibit fast inactivation.


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