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Issues

ISSN 0022-1295
EISSN 1540-7748

Generally Physiological

Meeting Summary

Review

Commentary

Research Articles

The prokaryotic ligand-gated channel ELIC opens to two open states when maximally activated by the binding of at least two agonist molecules.

The permeant ion nitrate modulates CFTR gating to increase its open probability through a mechanism similar to that of VX-770.

Phenylalanine 380 and leucine 377 in the BK channel S6 transmembrane helix of contiguous subunits participate in a hydrophobic interaction in both the closed and open state; this interaction is important in the allosteric coupling between the Ca2+ and voltage sensors and pore domain.

Letter to the Editor

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