Cover picture: (Left) Scanning electron micrographs of an outer hair cell hair bundle from a mouse harboring null mutations in transmembrane channel–like protein isoforms 1 and 2. The bundle possesses tip links (bottom, arrows) thought to deliver force to the mechanotransducer channels. (Right) Mechanotransducer currents in mutants, unlike those in wild type, are activated by negative deflections of the bundle and are insensitive to BAPTA (see research article by Kim et al., 493–505).
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