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1 August 2013
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Cover Image
Cover picture: Expression of the muscarinic-activated K+ channel protein Girk4 (red, middle) in the sino-atrial node (SAN) region and its boundaries, the superior vena cava and the right atrium. SAN pacemaker cells, identified here with an antibody against the HCN4 channel isoform (green, left), coexpress Girk4 and HCN4 (right). CT, crista terminalis; IVC, inferior vena cava; RA, right atrium; SVC, superior vena cava (see research article by Mesirca et al., 113–126).
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ISSN 0022-1295
EISSN 1540-7748
Generally Physiological
Commentary
Article
The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation
Pietro Mesirca,Laurine Marger,Futoshi Toyoda,Riccardo Rizzetto,Matthieu Audoubert,Stefan Dubel,Angelo G. Torrente,Mattia L. DiFrancesco,Jana Christina Muller,Anne-Laure Leoni,Brigitte Couette,Joël Nargeot,David E. Clapham,Kevin Wickman,Matteo E. Mangoni
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