1 February 2012
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Cover Image
Cover Image
Cover picture: An individual myosin V, labeled with a bifunctional rhodamine probe at fixed angle, θP , φP on its lever arm (top, no. 2) and stepping on actin, is analyzed by polarized total internal reflection microscopy (bottom). Time-resolved probe orientations are initially measured in a laboratory coordinate frame (bottom) and transformed into an actin frame (top, no. 1), giving probe angles βP , αP . A novel analysis allowed Lewis et al. to determine θP , φP in the lever frame (top, no. 2), which is used with measured probe angles, βP , αP , to calculate the physiologically relevant lever orientations, βL , αL (top, no. 3; see article by Lewis et al., 101–120).
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ISSN 0022-1295
EISSN 1540-7748
