Issues

Design principles for K⁺ selectivity in membrane transport

Weakly acidic, but strongly irritating: TRPA1 and the activation of nociceptors by cytoplasmic acidification

A TRPA1-dependent mechanism for the pungent sensation of weak acids

Lens intracellular hydrostatic pressure is generated by the circulation of sodium and modulated by gap junction coupling

A kinetic analysis of protein transport through the anthrax toxin channel

Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume

Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

An electrostatic potassium channel opener targeting the final voltage sensor transition

Ion access pathway to the transmembrane pore in P2X receptor channels

Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide–gated channels

Massive calcium–activated endocytosis without involvement of classical endocytic proteins

Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains