Issues

Cover picture: (Top) Cartoons depicting translocation of lethal factor (LF) tagged with biotin (orange) through the anthrax toxin channel. (Bottom) Transbilayer currents in response to a series of voltage pulses (+80 mV for 5 s and −40 mV for 15 s) after LF is added to the cis side of the bilayer show unblocking of the channel in each cycle (blue line). The decrease of unblocking (red curve) after the addition of streptavidin to the trans side implies that the biotin residue at residue 1 of LF reaches the trans side of the channel (see article by Basilio et al., 343–356).