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Volume 136, Issue 6

1 December 2010

Journal of General Physiology Cover Image for Volume 136, Issue 6

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Cover Image

Cover Image

Cover picture: Proposed relative motion between transmembrane helices S0 and S4 in the BK_Ca voltage sensor. At rest (top left), W203 (outside S4) quenches a fluorophore (TMRM) labeling S0. Upon depolarization, S0 and S4 move apart, separating W203 from TMRM (top right), causing a large fluorescence increase (bottom; red trace). In W203V mutants, TMRM is not quenched (middle) and exhibits a negligible fluorescence increase on depolarization (bottom; blue trace) (see article by Pantazis et al., 645–657).
Table of Contents
Editorial Board

ISSN 0022-1295

EISSN 1540-7748

In this Issue

Review
Commentary
Article

Review

3₁₀ helices in channels and other membrane proteins

Ricardo Simão Vieira-Pires,João Henrique Morais-Cabral

View Articletitled, 3<sub>10</sub> helices in channels and other membrane proteins

Commentary

Relaxing messages from the sarcolemma

Giovanni Zifarelli,Michael Pusch

View Articletitled, Relaxing messages from the sarcolemma

Article

Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle

John D. Lueck,Ann E. Rossi,Charles A. Thornton,Kevin P. Campbell,Robert T. Dirksen

View Articletitled, Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle

Protein kinase A–induced myofilament desensitization to Ca²⁺ as a result of phosphorylation of cardiac myosin–binding protein C

Peter P. Chen,Jitandrakumar R. Patel,Inna N. Rybakova,Jeffery W. Walker,Richard L. Moss

View Articletitled, Protein kinase A–induced myofilament desensitization to Ca<sup>2+</sup> as a result of phosphorylation of cardiac myosin–binding protein C

Position and motions of the S4 helix during opening of the Shaker potassium channel

L. Revell Phillips,Kenton J. Swartz

View Articletitled, Position and motions of the S4 helix during opening of the Shaker potassium channel

Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK_Ca channel

Antonios Pantazis,Azadeh P. Kohanteb,Riccardo Olcese

View Articletitled, Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK<sub>Ca</sub> channel

On the mechanism of CFTR inhibition by a thiazolidinone derivative

Zoia Kopeikin,Yoshiro Sohma,Min Li,Tzyh-Chang Hwang

View Articletitled, On the mechanism of CFTR inhibition by a thiazolidinone derivative

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

Annette Lis,Susanna Zierler,Christine Peinelt,Andrea Fleig,Reinhold Penner

View Articletitled, A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

Unitary Ca²⁺ current through recombinant type 3 InsP₃ receptor channels under physiological ionic conditions

Horia Vais,J. Kevin Foskett,Don-On Daniel Mak

View Articletitled, Unitary Ca<sup>2+</sup> current through recombinant type 3 InsP<sub>3</sub> receptor channels under physiological ionic conditions

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JGP 100th Anniversary

Carriers, exchangers, and cotransporters in the first 100 years of the Journal of General Physiology

The physical basis of osmosis

Voltage-Gated Na Channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Mechanotransduction by Membrane Proteins

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

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