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1 August 2010
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Cover Image
Cover Image
Cover picture: A schematic model for the local control of EC coupling and ET coupling in nerve and muscle. In this model, AKAP150 targets PKCα, PKA, and PP2B to specific regions of the membrane where they modulate the gating modalities of a subpopulation of Cav1.2 channels. Together, this signaling pentad constitutes a regulatory module that controls local Ca2+ influx, excitation–contraction coupling, and NFAT-dependent gene transcription (see Perspective by Santana and Navedo, 143–147).
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ISSN 0022-1295
EISSN 1540-7748
Perspective
Perspectives on: Local calcium signaling
Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp
Perspectives on: Local calcium signaling
Deciphering ryanodine receptor array operation in cardiac myocytes
Perspectives on: Local calcium signaling
Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity
Perspectives on: Local calcium signaling
Natural inequalities: why some L-type Ca2+ channels work harder than others
Perspectives on: Local calcium signaling
