Issues

Cover picture: (Top) Cartoon representation of the mechanism of TRPV1 potentiation by NGF. NGF binding to trkA leads to PI3K activation. PI3K converts PIP2 to PIP3, which leads to a net increase in TRPV1 channels in the plasma membrane. Stein et al. provide support for this PI3K model of NGF potentiation (bottom right) and argue against an alternative PLC model (bottom left) (see article by Stein et al., 509–522).