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Molecular basis of disease and therapy in the nervous system

We are pleased to present a collection of articles on the molecular basis of disease an

Neurological and psychiatric disorders result from the disruption of a range of different cellular processes, including cell-cell communication, intracellular signaling and cellular homeostasis. At the heart of these processes is a cell membrane and a vast array of membrane proteins that together regulate the distribution of solutes and small molecules between the inside and outside of each cell. When membrane physiology is disturbed, disease can ensue. Equally, the lipids and proteins that govern membrane physiology also represent potential targets for therapy. The articles in this collection explore some of these pathophysiological mechanisms and reveal hope for developing new treatments for these diseases.

We hope you enjoy reading the articles, which are all freely available for a limited period.

Image © 2019 Shi et al.

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Cole S. Bailey; Hans J. Moldenhauer; Su Mi Park; Sotirios Keros; Andrea L. Meredith
DOI: 10.1085/jgp.201912457
Federica Gasparri; Jesper Wengel; Thomas Grutter; Stephan A. Pless
DOI: 10.1085/jgp.201912347
Sidharth Tyagi; Tyler R. Bendrick; Dilyana Filipova; Symeon Papadopoulos; Roger A. Bannister
DOI: 10.1085/jgp.201812237
Ruchi Kapoor; Thasin A. Peyear; Roger E. Koeppe, II; Olaf S. Andersen
DOI: 10.1085/jgp.201812263
Amol V. Shivange; Philip M. Borden; Anand K. Muthusamy; Aaron L. Nichols; Kallol Bera; Huan Bao; Ishak Bishara; Janice Jeon; Matthew J. Mulcahy; Bruce Cohen; Saidhbhe L. O'Riordan; Charlene Kim; Dennis A. Dougherty; Edwin R. Chapman; Jonathan S. Marvin; Loren L. Looger; Henry A. Lester
DOI: 10.1085/jgp.201812201
Edward Y. Shi; Christine L. Yuan; Matthew T. Sipple; Jayasri Srinivasan; Christopher P. Ptak; Robert E. Oswald; Linda M. Nowak
DOI: 10.1085/jgp.201812209
Rocio K. Finol-Urdaneta; Jeffrey R. McArthur; Marcel P. Goldschen-Ohm; Rachelle Gaudet; Denis B. Tikhonov; Boris S. Zhorov; Robert J. French
DOI: 10.1085/jgp.201812278
Rene Barro-Soria
DOI: 10.1085/jgp.201812221
Timothy J. Wilding; James E. Huettner
DOI: 10.1085/jgp.201812234
Drew C. Tilley; Juan M. Angueyra; Kenneth S. Eum; Heesoo Kim; Luke H. Chao; Anthony W. Peng; Jon T. Sack
DOI: 10.1085/jgp.201812213
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