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Structure, function, and pharmacology of ion channels

We are pleased to present a collection of articles on the structure, function and pharmacology of ion channels, which have been curated from recent issues of JGP.

Ion channels are transmembrane proteins that are critical components of both excitable and non-excitable cells. Without ion channels, neurons would not be able to communicate with other cells, muscle would not be able to contract and our immune system would not be able to fight infection. Indeed, when ion channels go awry, disease often follows.

The articles in this collection provide fundamental insights into the structure, function and pharmacology of a number of different ligand- and voltage-gated ion channels. Such insights will ultimately support the development of new and specific drugs to target monogenic, multigenic, and acquired disease.

We hope you enjoy these articles, all of which are freely available for a limited period.

Image © 2019 Fryatt et al.

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Danna Morales; Tamara Hermosilla; Diego Varela
DOI: 10.1085/jgp.201812236
Kazuharu Furutani; Kunichika Tsumoto; I-Shan Chen; Kenichiro Handa; Yuko Yamakawa; Jon T. Sack; Yoshihisa Kurachi
DOI: 10.1085/jgp.201812192
Alistair G. Fryatt; Sudad Dayl; Anastasios Stavrou; Ralf Schmid; Richard J. Evans
DOI: 10.1085/jgp.201812108
Edward Y. Shi; Christine L. Yuan; Matthew T. Sipple; Jayasri Srinivasan; Christopher P. Ptak; Robert E. Oswald; Linda M. Nowak
DOI: 10.1085/jgp.201812209
Rocio K. Finol-Urdaneta; Jeffrey R. McArthur; Marcel P. Goldschen-Ohm; Rachelle Gaudet; Denis B. Tikhonov; Boris S. Zhorov; Robert J. French
DOI: 10.1085/jgp.201812278
Vinay Idikuda; Weihua Gao; Zhuocheng Su; Qinglian Liu; Lei Zhou
DOI: 10.1085/jgp.201812019
Yu Patrick Shi; Samrat Thouta; Yen May Cheng; Tom W. Claydon
DOI: 10.1085/jgp.201812137
Timothy J. Wilding; James E. Huettner
DOI: 10.1085/jgp.201812234
Sara J. Codding; Matthew C. Trudeau
DOI: 10.1085/jgp.201812129
Drew C. Tilley; Juan M. Angueyra; Kenneth S. Eum; Heesoo Kim; Luke H. Chao; Anthony W. Peng; Jon T. Sack
DOI: 10.1085/jgp.201812213
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