Responses of receptor cells in the frog's olfactory epithelium were recorded using platinum-black metal-filled microelectrodes. Spontaneous activity varied over a wide range from 0.07 to 1.8 spikes/s. Mean interspike intervals ranged from 13.7 to 0.5 s. Excitatory responses to six sterically related compounds at low concentrations were investigated. Stimuli were delivered in an aqueous medium. Thresholds for impulse initiation varied from greater than 1 mM down to the nanomolar concentration range. Thresholds of different olfactory receptors to the same stimulus could vary by several log units. Thresholds of the same receptor cell to different stimuli could be within the same order of magnitude, or could vary by as much as 5 log units. Based upon quantitative measures of stimulus-evoked excitatory responses it appeared that some receptors did not discriminate among sterically related molecules, whereas other receptors clearly discriminated between stimuli which evoke similar odor sensations.
Article| August 01 1974
Unitary Responses in Frog Olfactory Epithelium to Sterically Related Molecules at Low Concentrations
Thomas V. Getchell
From the Monell Chemical Senses Center and Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Dr. Getchell's present address is the Department of Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Received: October 10 1973
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright © 1974 by The Rockefeller University Press
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Thomas V. Getchell; Unitary Responses in Frog Olfactory Epithelium to Sterically Related Molecules at Low Concentrations . J Gen Physiol 1 August 1974; 64 (2): 241–261. doi: https://doi.org/10.1085/jgp.64.2.241
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