Insulin in low concentrations inhibits the uptake of Ca++ by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca++ adsorbed to the monolayer. These effects of insulin are more pronounced at higher insulin concentrations. Evidence is presented that a relatively intact insulin molecule competes with Ca++ for the free phosphate group of the monolayer. Albumin has a slight inhibitory action on calcium uptake and parathyroid hormone has no observable action on calcium uptake or release.

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