In frog sartorius muscle fibers in which the transverse tubular system has been disrupted by treatment with glycerol, action potentials which are unaccompanied by twitches can be recorded. These action potentials appear to be the same as those recorded in normal fibers except that the early afterpotential usually consists of a small hyperpolarization of short duration. After a train of action potentials no late afterpotential is seen even when the membrane potential is changed from the resting level. In fibers without transverse tubules hyperpolarizing currents do not produce a creep in potential. The interruption of excitation-contraction coupling, the changes in the afterpotentials, and the disappearance of creep are all attributed to the lack of a transverse tubular system.
Article|
March 01 1969
Action Potentials, Afterpotentials, and Excitation-Contraction Coupling in Frog Sartorius Fibers without Transverse Tubules
Peter W. Gage
,
Peter W. Gage
From the Department of Physiology, Duke University, Durham, North Carolina 27706.
Search for other works by this author on:
Robert S. Eisenberg
Robert S. Eisenberg
From the Department of Physiology, Duke University, Durham, North Carolina 27706.
Search for other works by this author on:
Peter W. Gage
From the Department of Physiology, Duke University, Durham, North Carolina 27706.
Robert S. Eisenberg
From the Department of Physiology, Duke University, Durham, North Carolina 27706.
Dr. Gage's present address is Department of Physiology, University of New South Wales, Kensington, Australia. Dr. Eisenberg's present address is Department of Physiology, University of California at Los Angeles, Los Angeles, California 90024
Received:
October 25 1968
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright © 1969 by The Rockefeller University Press
1969
J Gen Physiol (1969) 53 (3): 298–310.
Article history
Received:
October 25 1968
Citation
Peter W. Gage, Robert S. Eisenberg; Action Potentials, Afterpotentials, and Excitation-Contraction Coupling in Frog Sartorius Fibers without Transverse Tubules . J Gen Physiol 1 March 1969; 53 (3): 298–310. doi: https://doi.org/10.1085/jgp.53.3.298
Download citation file:
Close