Somata of pacemaker and nonpacemaker neurons were isolated by ligatures tied around the axons between the somata and the synaptic regions, and the transmembrane potentials of the isolated somata were recorded. Isolated somata of pacemaker neurons had a spontaneous discharge while isolated somata of nonpacemaker neurons were quiescent. In addition, the time course of accommodation in isolated somata of pacemaker and nonpacemaker neurons was found to be different. In pacemaker neurons, injection of current produced a change in rate of discharge sustained for the duration of current injection, while in nonpacemakers, current injection produced only a transient change in discharge rate. Evidence is presented that the pacemaker locus and spike trigger zone in the intact pacemaker neuron are located on the soma.

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