Certain inhibitors of nucleic acid and protein synthesis, namely actinomycin D, mitomycin C, and puromycin, have been found to block the expression of a persistent daily rhythm of bioluminescence. The action does not inhibit luminescence per se but rather the rhythmicity. Exposure of the cells to these inhibitors for only a few hours, which might be expected to thereby delay the rhythm by a few hours, does not in fact have this effect. Chloramphenicol and amethopterin do not inhibit the rhythm. It is proposed that the functioning of the clock-like rhythmic mechanism depends upon the cell's normal ability to synthesize RNA.
The Effects of Inhibitors of Macromolecular Biosynthesis upon the Persistent Rhythm of Luminescence in Gonyaulax
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Marlene W. Karakashian, J. Woodland Hastings; The Effects of Inhibitors of Macromolecular Biosynthesis upon the Persistent Rhythm of Luminescence in Gonyaulax . J Gen Physiol 1 September 1963; 47 (1): 1–12. doi: https://doi.org/10.1085/jgp.47.1.1
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