A study has been made of the distribution and properties of the free amino acid pool in yeast. The depletion of the pool was found to depend upon the energy source used, conditions of growth, and the nature of the exogenous nitrogen source. Pool levels could be restored either by an internal replenishment mechanism or by various nitrogen sources. In the absence of internal replenishment a strong positive correlation was established between the ability of nitrogen compounds to support free glutamic add synthesis and enzyme-synthesizing capacity. Amino acid assimilation by nitrogen-starved yeast was studied and compared with that in other organisms. The significance of these results for the problem of enzyme and protein synthesis in yeast is discussed.
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March 20 1955
A STUDY OF THE PROPERTIES OF THE FREE AMINO ACID POOL AND ENZYME SYNTHESIS IN YEAST
Harlyn Halvorson
,
Harlyn Halvorson
From the Department of Bacteriology, University of Michigan, Ann Arbor
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William Fry
,
William Fry
From the Department of Bacteriology, University of Michigan, Ann Arbor
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Donald Schwemmin
Donald Schwemmin
From the Department of Bacteriology, University of Michigan, Ann Arbor
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Harlyn Halvorson
From the Department of Bacteriology, University of Michigan, Ann Arbor
William Fry
From the Department of Bacteriology, University of Michigan, Ann Arbor
Donald Schwemmin
From the Department of Bacteriology, University of Michigan, Ann Arbor
Received:
August 27 1954
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright, 1955, by The Rockefeller Institute for Medical Research
1955
J Gen Physiol (1955) 38 (4): 549–573.
Article history
Received:
August 27 1954
Citation
Harlyn Halvorson, William Fry, Donald Schwemmin; A STUDY OF THE PROPERTIES OF THE FREE AMINO ACID POOL AND ENZYME SYNTHESIS IN YEAST . J Gen Physiol 20 March 1955; 38 (4): 549–573. doi: https://doi.org/10.1085/jgp.38.4.549
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