In early September, I took a trip to Woods Hole, where Incoming Editor-in-Chief Sharona Gordon and I attended the 67th Annual Meeting of the Society of General Physiologists. This year’s meeting saw the unveiling of the Society’s Friends of Physiology Lecture Series Honoring Clara Franzini-Armstrong and Clay Armstrong.

Clay, who has devoted many years to investigating ion channel permeability mechanisms and gating processes, and Clara, who has spent many years investigating the structural bases of excitation–contraction coupling, were gracious enough to allow Sharona and me to record a conversation in which we discussed some of their work. In this month’s installment of Generally Physiological, we’re delighted to present a condensed version of that conversation in what will be the first of an occasional series of audio presentations of conversations with notable physiologists.

The interview and transcript are available.

Listeners inspired to learn more about the studies Clara and Clay spoke about may wish to explore some of their pertinent JCB and JGP articles.

References

References
Franzini-Armstrong
C.
,
Porter
K.R.
.
1964
.
Sarcolemmal invaginations constituting the T system in fish muscle fibers
.
J. Cell Biol.
22
:
675
696
.
Block
B.A.
,
Imagawa
T.
,
Campbell
K.P.
,
Franzini-Armstrong
C.
.
1988
.
Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle
.
J. Cell Biol.
107
:
2587
2600
.
Sun
X.H.
,
Protasi
F.
,
Takahashi
M.
,
Takeshima
H.
,
Ferguson
D.G.
,
Franzini-Armstrong
C.
.
1995
.
Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle
.
J. Cell Biol.
129
:
659
671
.
Protasi
F.
,
Franzini-Armstrong
C.
,
Allen
P.D.
.
1998
.
Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle
.
J. Cell Biol.
140
:
831
842
.
Di Biase
V.
,
Franzini-Armstrong
C.
.
2005
.
Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery
.
J. Cell Biol.
171
:
695
704
.
Armstrong
C.M.
,
Binstock
L.
.
1965
.
Anomalous rectification in the squid giant axon injected with tetraethylammonium chloride
.
J. Gen. Physiol.
48
:
859
872
.
Armstrong
C.M.
1966
.
Time course of TEA+-induced anomalous rectification in squid giant axons
.
J. Gen. Physiol.
50
:
491
503
.
Armstrong
C.M.
1969
.
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons
.
J. Gen. Physiol.
54
:
553
575
.
Armstrong
C.M.
1971
.
Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
.
J. Gen. Physiol.
58
:
413
437
.
Armstrong
C.M.
,
Bezanilla
F.
,
Rojas
E.
.
1973
.
Destruction of sodium conductance inactivation in squid axons perfused with pronase
.
J. Gen. Physiol.
62
:
375
391
.