1. The respiration of Amoeba proteus was measured. 10 c. mm. of cells were found to use about 1.6 mm.3 of oxygen per hour at 20°C. The respiratory quotient was found to be nearly unity.

2. No anaerobic metabolism was found for Amoeba.

3. The respiration of Blepharisma was found to be from 3 to 7 mm.3 oxygen per hour for 10 mm.3 cells. The respiratory quotient was about 1.

4. Blepharisma was shown to have a definite anaerobic metabolism. 80 mm.3 cells caused the evolution of 12.5 mm.3 carbon dioxide per hour at 20°C. in the presence of bicarbonate.

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