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Correction| December 01 1997

The Journal of General Physiology. Volume 110, No. 4, October 1997.

Kontis,

Kontis

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K.J.,

K.J.

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A.L. Goldin.

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Author and Article Information

Kontis

K.J.

A.L. Goldin.

Online ISSN: 1540-7748

Print ISSN: 0022-1295

1997

J Gen Physiol (1997) 110 (6): 765.

https://doi.org/10.1085/jgp.110.6.765

Page 403.

Table IV referred to previous data from Chen et al. (1996) concerning mutations in domain IV of the sodium channel. However, the numbering system for mutations in domain IV used by Chen et al. (1996) differed from that used in this paper. Therefore, two mutants were labeled incorrectly. Mutant 4R1Q should have been termed 4R0Q, and mutant 4R3Q should have been termed 4R2Q. The corrected table is reprinted below.

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1997

Table IV

Summary of Charge Neutralization Mutation Effects on Fast Inactivation

Channel	v_1/2 shift^*	a_h change^*
	mV
1R1Q^‡	−0.8	−0.2
1R1Q^§	−5.0	−0.8
1R2Q	−5.1^‖	−1.0^‖
1R2Q^§	−6.0	−0.5
1R3Q^‡	−5.8	−1.1^‖
1R3Q^§	+6.0	+1.4
1K4Q	−3.7^‖	−0.4^‖
1K4Q^§	−6.0	+0.9
2R1Q^‡	+8.2^‖	−0.4
2R2Q	−8.1^‖	−0.8^‖
2R3Q^‡	−9.6^‖	−1.1^‖
2K4Q	−5.7^‖	−0.6^‖
2K5Q^§	−9.0	−0.8
3K1Q^‡	−21.0^‖	−0.8^‖
3R2Q	−8.5^‖	−0.9^‖
3R3Q^‡	−10.6^‖	−0.6
3R4Q	−3.2^‖	0.0
4R0Q^‡	+4.7^‖	−2.0^‖
4R2Q	−0.6	−0.5^‖
4R2Q^‡	−57.5^‖	−2.6^‖
4R4Q	+0.2	+0.3

Channel	v_1/2 shift^*	a_h change^*
	mV
1R1Q^‡	−0.8	−0.2
1R1Q^§	−5.0	−0.8
1R2Q	−5.1^‖	−1.0^‖
1R2Q^§	−6.0	−0.5
1R3Q^‡	−5.8	−1.1^‖
1R3Q^§	+6.0	+1.4
1K4Q	−3.7^‖	−0.4^‖
1K4Q^§	−6.0	+0.9
2R1Q^‡	+8.2^‖	−0.4
2R2Q	−8.1^‖	−0.8^‖
2R3Q^‡	−9.6^‖	−1.1^‖
2K4Q	−5.7^‖	−0.6^‖
2K5Q^§	−9.0	−0.8
3K1Q^‡	−21.0^‖	−0.8^‖
3R2Q	−8.5^‖	−0.9^‖
3R3Q^‡	−10.6^‖	−0.6
3R4Q	−3.2^‖	0.0
4R0Q^‡	+4.7^‖	−2.0^‖
4R2Q	−0.6	−0.5^‖
4R2Q^‡	−57.5^‖	−2.6^‖
4R4Q	+0.2	+0.3

v_1/2 and a_h are the half-maximal voltage and slope factor for fast inactivation. Data from Stühmer et al. (1989) did not include an assessment of statistical significance.

‡

Data from Chen et al. (1966).

Data from Stühmer et al. (1989). These data were acquired using a 100-ms prepulse, whereas all other data were acquired using a 500-ms prepulse.

‖

Values statistically significant, with a probability <0.05 resulting from random variation.

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The Journal of General Physiology. Volume 110, No. 4, October 1997.

Page 403.

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