It is pointed out that there are great advantages in using single cells instead of tissues in the study of bioelectrical phenomena.

Certain bioelectrical phenomena are discussed in relation to the structure of protoplasm.

Under certain circumstances measurements of potential differences may enable us to determine what ions enter the protoplasm.

Under suitable conditions we are able to ascertain the potential differences across the protoplasm at single points, instead of being obliged merely to measure the differences between two points.

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