1. In concentrations which are high enough to produce any effect, formaldehyde, ether, and acetone cause an increase, followed by a decrease, in the rate of respiration.

2. 3.65 per cent ether, which causes an increase with certain cultures, produces only a decrease with others.

3. The reaction producing an increase in the respiration with 7.3 per cent ether is a reversible process, while the reaction producing the decrease is not reversible.

4. 0.5 per cent caffeine produces only a decrease in respiration while a saturated solution causes an increase, which is followed by a decrease.

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