Albrecht, M.A., S.L. Colegrove, and D.D. Friel

The Journal of General Physiology . Volume 119, No. 3, March 2002. 211–233.

Page 221

The abscissa of Fig. 5 D was not labeled and did not correspond to the inset. The corrected figure appears below:

Figure 5.
Figure 5. Reconstruction of t-BuBHQ-induced [Ca2+]i transients and their modification by caffeine and ryanodine. Simulated effects of sudden inhibition of ER Ca2+ uptake on ci (∼[Ca2+]i, A), JRelease (B), and intraluminal Ca2+ concentration, cER (∼\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{{\Delta}}\left[\mathrm{Ca}^{2\mathrm{+}}\right]_{\mathrm{ER}}^{\left(\mathrm{i}\right)}\left(\mathrm{t}\right)\) \end{document}). Simulations were performed as described in appendix B using experimentally determined descriptions of κi from Fig. 1 D, JSERCA from Fig. 2 C, and PER(vi/vERκER) from Fig. 4 D. Jpm was described by smooth curves obtained from analysis of individual cells from Fig. 4 as in Fig. 3 C, with initial values of ci based on estimates of resting [Ca2+]i in those same cells. Insets in A and B show simulations performed assuming a fixed initial value (50 nM) for ci.
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Reconstruction of t-BuBHQ-induced [Ca2+]i transients and their modification by caffeine and ryanodine. Simulated effects of sudden inhibition of ER Ca2+ uptake on ci (∼[Ca2+]i, A), JRelease (B), and intraluminal Ca2+ concentration, cER (∼

\(\mathrm{{\Delta}}\left[\mathrm{Ca}^{2\mathrm{+}}\right]_{\mathrm{ER}}^{\left(\mathrm{i}\right)}\left(\mathrm{t}\right)\)
⁠). Simulations were performed as described in appendix B using experimentally determined descriptions of κi from Fig. 1 D, JSERCA from Fig. 2 C, and PER(vi/vERκER) from Fig. 4 D. Jpm was described by smooth curves obtained from analysis of individual cells from Fig. 4 as in Fig. 3 C, with initial values of ci based on estimates of resting [Ca2+]i in those same cells. Insets in A and B show simulations performed assuming a fixed initial value (50 nM) for ci.

Figure 5.
Figure 5. Reconstruction of t-BuBHQ-induced [Ca2+]i transients and their modification by caffeine and ryanodine. Simulated effects of sudden inhibition of ER Ca2+ uptake on ci (∼[Ca2+]i, A), JRelease (B), and intraluminal Ca2+ concentration, cER (∼\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{{\Delta}}\left[\mathrm{Ca}^{2\mathrm{+}}\right]_{\mathrm{ER}}^{\left(\mathrm{i}\right)}\left(\mathrm{t}\right)\) \end{document}). Simulations were performed as described in appendix B using experimentally determined descriptions of κi from Fig. 1 D, JSERCA from Fig. 2 C, and PER(vi/vERκER) from Fig. 4 D. Jpm was described by smooth curves obtained from analysis of individual cells from Fig. 4 as in Fig. 3 C, with initial values of ci based on estimates of resting [Ca2+]i in those same cells. Insets in A and B show simulations performed assuming a fixed initial value (50 nM) for ci.
View large Download slide

Reconstruction of t-BuBHQ-induced [Ca2+]i transients and their modification by caffeine and ryanodine. Simulated effects of sudden inhibition of ER Ca2+ uptake on ci (∼[Ca2+]i, A), JRelease (B), and intraluminal Ca2+ concentration, cER (∼

\(\mathrm{{\Delta}}\left[\mathrm{Ca}^{2\mathrm{+}}\right]_{\mathrm{ER}}^{\left(\mathrm{i}\right)}\left(\mathrm{t}\right)\)
⁠). Simulations were performed as described in appendix B using experimentally determined descriptions of κi from Fig. 1 D, JSERCA from Fig. 2 C, and PER(vi/vERκER) from Fig. 4 D. Jpm was described by smooth curves obtained from analysis of individual cells from Fig. 4 as in Fig. 3 C, with initial values of ci based on estimates of resting [Ca2+]i in those same cells. Insets in A and B show simulations performed assuming a fixed initial value (50 nM) for ci.

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The Rockefeller University Press
2002