Previous studies based upon competition between different organic anions for biliary excretion in vivo have suggested that all organic anions share a common hepatic secretory mechanism. Corriedale sheep with an inherited defect in organic anion excretion by the liver were used to study this problem directly without the need for competition studies, the results of which are difficult to analyze. Maximal biliary excretion of sulfobromphthalein (BSP) in mutant Corriedale sheep was less than 7% of that observed in normal sheep whereas maximal biliary excretion of taurocholate, the major organic anion in sheep bile, was not different in mutant and normal sheep. Taurocholate infusion enhanced maximal hepatic excretion of BSP in normal but not in mutant sheep. These studies of an inheritable disorder which appears to be identical to the Dubin-Johnson syndrome in man, demonstrate that taurocholate excretion requires at least one step in biliary excretion which is not required by other organic anions such as bile pigment, porphyrins, drugs, and dyes.
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1 February 1969
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February 01 1969
Multiplicity of Hepatic Excretory Mechanisms for Organic Anions
Seymour Alpert,
Seymour Alpert
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
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Michael Mosher,
Michael Mosher
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
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Alan Shanske,
Alan Shanske
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
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Irwin M. Arias
Irwin M. Arias
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
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Seymour Alpert
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
Michael Mosher
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
Alan Shanske
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
Irwin M. Arias
From the Departments of Medicine and Surgery, Albert Einstein College of Medicine, Bronx, New York, and the Bronx Municipal Hospital Center, Bronx, New York 10461
Received:
February 07 1968
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright © 1969 by The Rockefeller University Press
1969
J Gen Physiol (1969) 53 (2): 238–247.
Article history
Received:
February 07 1968
Citation
Seymour Alpert, Michael Mosher, Alan Shanske, Irwin M. Arias; Multiplicity of Hepatic Excretory Mechanisms for Organic Anions . J Gen Physiol 1 February 1969; 53 (2): 238–247. doi: https://doi.org/10.1085/jgp.53.2.238
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