The molecular identity of the channels producing swelling-activated Cl conductance (gswell) is of great interest since this physiologic response to swelling is common to many cells. As presented in the May Perspectives (Clapham, 1998; Strange, 1998), the question of whether the observed gswell represents a family of channel proteins is presently unanswered, but to be included in this family a channel must be activated by cell swelling and conduct Cl. Determining if a candidate Cl channel should be included based on swelling sensitivity may be problematic since the volume-sensing element could reside in an auxiliary protein that associates with the channel protein and, through allosteric modulation, creates a swelling-activated complex. If the associated sensor is removed inadvertently by experimental manipulation or incomplete reconstitution, then a legitimate family member would be excluded. Permeation selectivity is intrinsic to the pore of the channel protein and...
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1 September 1998
Letter to the Editor|
September 01 1998
Identifying Swelling-activated Channels from Ion Selectivity Patterns : Letter to the Editor
Dan R. Halm
Dan R. Halm
From the Department of Physiology and Biophysics, Wright State University, Dayton, Ohio 45435
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Dan R. Halm
From the Department of Physiology and Biophysics, Wright State University, Dayton, Ohio 45435
Address correspondence to Dan R. Halm, Department of Physiology and Biophysics, Wright State University, Dayton, OH 45435. Fax: 937-775-3769; E-mail: [email protected]
Online ISSN: 1540-7748
Print ISSN: 0022-1295
1998
J Gen Physiol (1998) 112 (3): 369–371.
Citation
Dan R. Halm; Identifying Swelling-activated Channels from Ion Selectivity Patterns : Letter to the Editor. J Gen Physiol 1 September 1998; 112 (3): 369–371. doi: https://doi.org/10.1085/jgp.112.3.369
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