The protein for the swelling-activated chloride conductance is one of the few ion channels left for which we do not have a universally acceptable clone. In this brief note, I hope to describe why chloride channels in general, and ICl.swell in particular, have been difficult to pin down. Dr. Strange describes why he believes the pICln protein is not ICl.swell. I agree. In 1995 we demonstrated that pICln is unlikely to be a channel itself (Krapivinsky et al., 1994). Voets et al. (1996) also concludes that, although oocyte expression of pICln activates a chloride current, this chloride current is not ICl.swell. pICln is related to chloride channel activation, but how or why is not understood. In an attempt to place the arguments in a broader perspective, Table I lists most of the proposed chloride channel proteins that have been isolated and cloned...
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1 May 1998
Perspective|
May 01 1998
Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swell (and Shrink)
David E. Clapham
David E. Clapham
From the Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115
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David E. Clapham
From the Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115
Online ISSN: 1540-7748
Print ISSN: 0022-1295
1998
J Gen Physiol (1998) 111 (5): 623–624.
Citation
David E. Clapham; Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swell (and Shrink) . J Gen Physiol 1 May 1998; 111 (5): 623–624. doi: https://doi.org/10.1085/jgp.111.5.623
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