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Journal Articles

Correction: Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome

Mi Yang, Qi Guo, Hui Peng, Yu-Zhong Xiao, Ye Xiao, Yan Huang, Chang-Jun Li, Tian Su, Yun-Lin Zhang, Min-Xiang Lei, Hui-Ling Chen, Tie-Jian Jiang, Xiang-Hang Luo
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e2018155403172025C.
https://doi.org/10.1084/jem.2018155403172025C
Published: 24 March 2025
View article titled, Correction: Krüppel-like factor 3 inhibition by mutated lncRNA <em>Reg1cp</em> results in human high bone mass syndrome
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Journal Articles

Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells

Bradly M. Bauman, Jeffrey R. Stinson, Melissa A. Kallarakal, Lei Haley Huang, Andrew M. Frank, Gauthaman Sukumar, Nermina Saucier, Clifton L. Dalgard, Alice Y. Chan, Joshua D. Milner, Megan A. Cooper, Andrew L. Snow
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20240272.
https://doi.org/10.1084/jem.20240272
Published: 20 March 2025
View article titled, Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells
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Includes: Supplementary data
Journal Articles

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design

Kevin Groen, Roger Kuratli, Jannik Enkelmann, Sonja Fernbach, Pedro D. Wendel-Garcia, Willy I. Staiger, Marylène Lejeune, Esther Sauras-Colón, Ferran Roche-Campo, Paraskevas Filippidis, Andri Rauch, Swiss HIV Cohort Study, Alexandra Trkola, Huldrych F. Günthard, Roger D. Kouyos, Silvio D. Brugger, Benjamin G. Hale
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242039.
https://doi.org/10.1084/jem.20242039
Published: 20 March 2025
View article titled, Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
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Includes: Supplementary data
Journal Articles

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation

Dave Maurice De Sousa, Eric Perkey, Laure Le Corre, Salix Boulet, Daniela Gómez Atria, Anneka Allman, Frédéric Duval, Jean-François Daudelin, Joshua D. Brandstadter, Katlyn Lederer, Sarah Mezrag, Livia Odagiu, Myriam Ennajimi, Marion Sarrias, Hélène Decaluwe, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Ivan Maillard, Nathalie Labrecque
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20231758.
https://doi.org/10.1084/jem.20231758
Published: 20 March 2025
View article titled, Early Notch signals from fibroblastic reticular cells program effector CD8<sup>+</sup> T cell differentiation
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Includes: Supplementary data
Journal Articles

An in-depth look at lung lymphatics

David G. Jackson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250119.
https://doi.org/10.1084/jem.20250119
Published: 19 March 2025
View article titled, An in-depth look at lung lymphatics
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Journal Articles

Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance

Kerry L. Hilligan, Patricia A. Darrah, Robert A. Seder, Alan Sher
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20240496.
https://doi.org/10.1084/jem.20240496
Published: 18 March 2025
View article titled, Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance
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Journal Articles

Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella

Madeline J. Churchill, Ankit Pandeya, Renate Bauer, Tighe Christopher, Stefanie Krug, Roslyn Honodel, Shuchi Smita, Lindsey Warner, Bridget M. Mooney, Alexis R. Gibson, Patrick S. Mitchell, Elia D. Tait Wojno, Isabella Rauch
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20230803.
https://doi.org/10.1084/jem.20230803
Published: 13 March 2025
View article titled, Enteric tuft cell inflammasome activation drives NKp46<sup>+</sup>ILC3 IL22 via PGD<sub>2</sub> and inhibits <em>Salmonella</em>
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Includes: Supplementary data
Journal Articles

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

Geunhyo Jang, Rosa Park, Eduardo Esteva, Pei-Feng Hsu, Jue Feng, Samik Upadhaya, Catherine M. Sawai, Iannis Aifantis, David R. Fooksman, Boris Reizis
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20240587.
https://doi.org/10.1084/jem.20240587
Published: 12 March 2025
View article titled, Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system
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Includes: Supplementary data
Journal Articles

KLF family members control expression of genes required for tissue macrophage identities

Kathleen Pestal, Leianna C. Slayden, Gregory M. Barton
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20240379.
https://doi.org/10.1084/jem.20240379
Published: 12 March 2025
View article titled, KLF family members control expression of genes required for tissue macrophage identities
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Includes: Supplementary data
Journal Articles

Correction: Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e2023196702272025c.
https://doi.org/10.1084/jem.2023196702272025c
Published: 11 March 2025
View article titled, Correction: Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Journal Articles

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

Benjamin J. Broomfield, Chin Wee Tan, Raymond Z. Qin, Hanna Abberger, Brigette C. Duckworth, Carolina Alvarado, Lennard Dalit, Chee Leng Lee, Rekha Shandre Mugan, Zihnil A.I. Mazrad, Hiromi Muramatsu, Liana Mackiewicz, Bailey E. Williams, Jinjin Chen, Asuka Takanashi, Stewart Fabb, Marc Pellegrini, Kelly L. Rogers, Woohyun J. Moon, Colin W. Pouton, Melissa J. Davis, Stephen L. Nutt, Norbert Pardi, Verena C. Wimmer, Joanna R. Groom
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241148.
https://doi.org/10.1084/jem.20241148
Published: 10 March 2025
View article titled, Transient inhibition of type I interferon enhances CD8<sup>+</sup> T cell stemness and vaccine protection
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Includes: Supplementary data
Journal Articles

PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion

Wenxing Qin, Yuran Duan, Zhiqiang Hu, Yueru Hou, Ting Wen, Yuan Ouyang, Zheng Wang, Xue Sun, Xiaohan Chen, Katherine L. Wang, Shudi Luo, Guimei Ji, Yuli Shen, Bofei Dong, Yanni Lin, Qi Tian, Zhanpeng Guo, Shiqi Wu, Ling Xiao, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Wuchang Zhang, Shengzhong Duan, Xueli Bai, Tong Liu, Jie He, Zhimin Lu, Daqian Xu
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20240902.
https://doi.org/10.1084/jem.20240902
Published: 06 March 2025
View article titled, PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion
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Includes: Supplementary data
Journal Articles

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes

Hannah Peckham, Anna Radziszewska, Justyna Sikora, Nina M. de Gruijter, Restuadi Restuadi, Melissa Kartawinata, Lucia Martin-Gutierrez, George A. Robinson, Claire T. Deakin, Lucy R. Wedderburn, Elizabeth C. Jury, Gary Butler, Emma S. Chambers, Elizabeth C. Rosser, Coziana Ciurtin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20241253.
https://doi.org/10.1084/jem.20241253
Published: 06 March 2025
View article titled, Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes
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Includes: Supplementary data
Journal Articles

Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients

Evi Duthoo, Elien Beyls, Lynn Backers, Thorkell Gudjónsson, Peiquan Huang, Leander Jonckheere, Sebastian Riemann, Bram Parton, Likun Du, Veronique Debacker, Marieke De Bruyne, Levi Hoste, Ans Baeyens, Anne Vral, Eva Van Braeckel, Jens Staal, Geert Mortier, Tessa Kerre, Qiang Pan-Hammarström, Claus S. Sørensen, Filomeen Haerynck, Kathleen B.M. Claes, Simon J. Tavernier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241432.
https://doi.org/10.1084/jem.20241432
Published: 03 March 2025
View article titled, Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients
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Includes: Supplementary data
Journal Articles

The common HAQ STING allele prevents clinical penetrance of COPA syndrome

Noa Simchoni, Shogo Koide, Maryel Likhite, Yoshihiko Kuchitsu, Senkottuvelan Kadirvel, Christopher S. Law, Brett M. Elicker, Santosh Kurra, Margaret Mei-Kay Wong, Bo Yuan, Alice Grossi, Ronald M. Laxer, Stefano Volpi, Dilan Dissanayake, Tomohiko Taguchi, David B. Beck, Tiphanie P. Vogel, Anthony K. Shum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20242179.
https://doi.org/10.1084/jem.20242179
Published: 27 February 2025
View article titled, The common HAQ STING allele prevents clinical penetrance of COPA syndrome
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Includes: Supplementary data
Journal Articles

Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

Benjamin Israelow, Eric Song, Tianyang Mao, Peiwen Lu, Amit Meir, Feimei Liu, Mia Madel Alfajaro, Jin Wei, Huiping Dong, Robert J. Homer, Aaron Ring, Craig B. Wilen, Akiko Iwasaki
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e2020124102192025c.
https://doi.org/10.1084/jem.2020124102192025c
Published: 26 February 2025
View article titled, Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
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Journal Articles

Splicing factor RBM10 loss fuels thyroid cancer metastasis

Kevin Coughlin, Jr., Ledong Wan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250050.
https://doi.org/10.1084/jem.20250050
Published: 24 February 2025
View article titled, Splicing factor RBM10 loss fuels thyroid cancer metastasis
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Journal Articles

RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs

Gnana P. Krishnamoorthy, Anthony R. Glover, Brian R. Untch, Nickole Sigcha-Coello, Bin Xu, Dina Vukel, Yi Liu, Vera Tiedje, Jose Mario Bello Pineda, Katherine Berman, Prasanna P. Tamarapu, Adrian Acuña-Ruiz, Mahesh Saqcena, Elisa de Stanchina, Laura Boucai, Ronald A. Ghossein, Jeffrey A. Knauf, Omar Abdel-Wahab, Robert K. Bradley, James A. Fagin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241029.
https://doi.org/10.1084/jem.20241029
Published: 24 February 2025
View article titled, RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs
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Includes: Supplementary data
Journal Articles

KLF2 expression in IgG plasma cells at their induction site regulates the migration program

Wataru Ise, Takuya Koike, Nozomi Shimada, Hiromi Yamamoto, Yuki Tai, Taiichiro Shirai, Ryoji Kawakami, Mana Kuwabara, Chie Kawai, Kyoko Shida, Takeshi Inoue, Nozomi Hojo, Kenji Ichiyama, Shimon Sakaguchi, Katsuyuki Shiroguchi, Kazuhiro Suzuki, Tomohiro Kurosaki
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241019.
https://doi.org/10.1084/jem.20241019
Published: 20 February 2025
View article titled, KLF2 expression in IgG plasma cells at their induction site regulates the migration program
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Journal Articles

A “second hit” impacts disease severity in a dominantly inherited genetic skin disorder

Pierre A. Coulombe
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20242377.
https://doi.org/10.1084/jem.20242377
Published: 20 February 2025
View article titled, A “second hit” impacts disease severity in a dominantly inherited genetic skin disorder
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