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Journal Articles

Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis

Joan Shang, Diane Marie Del Valle, Graham J. Britton, K.R. Mead, Urvija Rajpal, Alice Chen-Liaw, Ilaria Mogno, Zhihua Li, Rajita Menon, Edgar Gonzalez-Kozlova, Arielle Elkrief, Jonathan U. Peled, Tina Ruth Gonsalves, Neil J. Shah, Michael Postow, Jean-Frederic Colombel, Sacha Gnjatic, David M. Faleck, Jeremiah J. Faith
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232079.
https://doi.org/10.1084/jem.20232079
Published: 12 December 2024
View article titled, Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis
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Includes: Supplementary data
Journal Articles

Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma

In Special Collection:
Tissue Microenvironment and Immune Memory
Jia Ming Nickolas Teo, Zhulin Chen, Weixin Chen, Rachael Julia Yuenyinn Tan, Qi Cao, Yingming Chu, Delin Ma, Liting Chen, Huajian Yu, Ka-Hei Lam, Terence Kin Wah Lee, Svetoslav Chakarov, Burkhard Becher, Ning Zhang, Zhao Li, Stephanie Ma, Ruidong Xue, Guang Sheng Ling
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241442.
https://doi.org/10.1084/jem.20241442
Published: 05 December 2024
View article titled, Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma
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Includes: Supplementary data
Journal Articles

Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis

Arja Ray, Kenneth H. Hu, Kelly Kersten, Tristan Courau, Nicholas F. Kuhn, Itzia Zaleta-Linares, Bushra Samad, Alexis J. Combes, Matthew F. Krummel
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240957.
https://doi.org/10.1084/jem.20240957
Published: 27 November 2024
View article titled, Targeting CD206<sup>+</sup> macrophages disrupts the establishment of a key antitumor immune axis
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Journal Articles

Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer

Huanhuan Joyce Chen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241581.
https://doi.org/10.1084/jem.20241581
Published: 25 November 2024
View article titled, Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer
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Journal Articles

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer

Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Francisco Expósito, Fernando de Miguel, James R. Knight, Francesc López-Giráldez, Hyejin Choi, Nicholas D. Socci, Taha Merghoub, Mark Awad, Gad Getz, Justin Gainor, Matthew D. Hellmann, Étienne Caron, Susan M. Kaech, Katerina Politi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20231106.
https://doi.org/10.1084/jem.20231106
Published: 25 November 2024
View article titled, Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View article titled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Includes: Supplementary data
Journal Articles

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kangkang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, Runhe Yan, Yulong Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yuchao Dong, Yanfang Liu, Xiaofei Yu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240959.
https://doi.org/10.1084/jem.20240959
Published: 15 November 2024
View article titled, MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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Includes: Supplementary data
Journal Articles

Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy

Hexin Shi, Dawson Medler, Jianhui Wang, Rachel Browning, Aijie Liu, Sara Schneider, Claudia Duran Bojorquez, Ashwani Kumar, Xiaohong Li, Jiexia Quan, Sara Ludwig, James J. Moresco, Chao Xing, Eva Marie Y. Moresco, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240797.
https://doi.org/10.1084/jem.20240797
Published: 29 October 2024
View article titled, Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy
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Includes: Supplementary data
Journal Articles

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

In Special Collection:
Tissue Microenvironment and Immune Memory , 2024: The Year in Experimental Medicine
Ian W. Folkert, William A. Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S. Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J. Lazar, Khalida Wani, William P. Israel, Zhan Zhang, Venkata S. Chaluvadi, Robert J. Norgard, Ying Liu, Ashley M. Fuller, Mai T. Dang, Robert E. Roses, Giorgos C. Karakousis, John T. Miura, Douglas L. Fraker, T.S. Karin Eisinger-Mathason, M. Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20230420.
https://doi.org/10.1084/jem.20230420
Published: 30 September 2024
View article titled, An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis
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Includes: Supplementary data
Journal Articles

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer

In Special Collection:
Cytokines Collection 2024
Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240152.
https://doi.org/10.1084/jem.20240152
Published: 27 August 2024
View article titled, Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer
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Includes: Supplementary data
Journal Articles

Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

Naijun Miao, Dongqing Cao, Jingsi Jin, Guizhi Ma, Haihui Yu, Junwen Qu, Guiping Li, Caixia Gao, Dong Dong, Fan Xia, Wenwen Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231486.
https://doi.org/10.1084/jem.20231486
Published: 21 August 2024
View article titled, Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8<sup>+</sup> T cell stemness maintenance
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Includes: Supplementary data
Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

In Special Collection:
Autoimmunity 2024
Minghong He, Xinying Zong, Beisi Xu, Wenjie Qi, Wenjun Huang, Mohamed Nadhir Djekidel, Yang Zhang, Vishwajeeth R. Pagala, Jun Li, Xiaolei Hao, Clifford Guy, Lu Bai, Richard Cross, Chunliang Li, Junmin Peng, Yongqiang Feng
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232068.
https://doi.org/10.1084/jem.20232068
Published: 27 June 2024
View article titled, Dynamic Foxp3–chromatin interaction controls tunable Treg cell function
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Includes: Supplementary data
Journal Articles

PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway

Jonathan J. Hodgins, John Abou-Hamad, Colin Edward O’Dwyer, Ash Hagerman, Edward Yakubovich, Christiano Tanese de Souza, Marie Marotel, Ariel Buchler, Saleh Fadel, Maria M. Park, Claire Fong-McMaster, Mathieu F. Crupi, Olivia Joan Makinson, Reem Kurdieh, Reza Rezaei, Harkirat Singh Dhillon, Carolina S. Ilkow, John C. Bell, Mary-Ellen Harper, Benjamin H. Rotstein, Rebecca C. Auer, Barbara C. Vanderhyden, Luc A. Sabourin, Marie-Claude Bourgeois-Daigneault, David P. Cook, Michele Ardolino
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20221721.
https://doi.org/10.1084/jem.20221721
Published: 13 June 2024
View article titled, PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway
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Includes: Supplementary data
Journal Articles

Personalized cancer T-cell therapy takes the stage, mirroring vaccine success

Johanna Chiffelle, Alexandre Harari
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (8): e20240854.
https://doi.org/10.1084/jem.20240854
Published: 11 June 2024
View article titled, Personalized cancer T-cell therapy takes the stage, mirroring vaccine success
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Journal Articles

Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis

In Special Collection:
Mechanisms and Models of Cancer 2024 , 2024: The Year in Experimental Medicine
Lingzi Hong, Tomasz Herjan, Xing Chen, Leah L. Zagore, Katarzyna Bulek, Han Wang, Chi-Fu Jeffrey Yang, Donny D. Licatalosi, Xiaoxia Li, Xiao Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20231442.
https://doi.org/10.1084/jem.20231442
Published: 11 June 2024
View article titled, Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis
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Includes: Supplementary data
Journal Articles

Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment

In Special Collection:
Mechanisms and Models of Cancer 2024
Michelle A. Tran, Dina Youssef, Sanjana Shroff, Disha Chowhan, Kristin G. Beaumont, Robert Sebra, Reza Mehrazin, Peter Wiklund, Jenny J. Lin, Amir Horowitz, Adam M. Farkas, Matthew D. Galsky, John P. Sfakianos, Nina Bhardwaj
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (8): e20240045.
https://doi.org/10.1084/jem.20240045
Published: 07 June 2024
View article titled, Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment
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Includes: Supplementary data
Journal Articles

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

In Special Collection:
Immunometabolism 2024 , Mechanisms and Models of Cancer 2024
Yun Xue, Yuting Chen, Sijia Sun, Xinyuan Tong, Yujia Chen, Shijie Tang, Xue Wang, Simin Bi, Yuqin Qiu, Qiqi Zhao, Zhen Qin, Qin Xu, Yingjie Ai, Leilei Chen, Beizhen Zhang, Zhijie Liu, Minbiao Ji, Meidong Lang, Luonan Chen, Guoliang Xu, Liang Hu, Dan Ye, Hongbin Ji
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20240111.
https://doi.org/10.1084/jem.20240111
Published: 28 May 2024
View article titled, TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition
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Includes: Supplementary data
Journal Articles

Radiotherapy and immunology

In Special Collection:
JEM Clinical Immunology Collection 2024 , Mechanisms and Models of Cancer 2024
Liangliang Wang, Connor Lynch, Sean P. Pitroda, András Piffkó, Kaiting Yang, Amy K. Huser, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (7): e20232101.
https://doi.org/10.1084/jem.20232101
Published: 21 May 2024
View article titled, Radiotherapy and immunology
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Journal Articles

Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy

In Special Collection:
Mechanisms and Models of Cancer 2024
Meng-Yin Lin, Eunwoo Nam, Ryan M. Shih, Amanda Shafer, Amber Bouren, Melanie Ayala Ceja, Caitlin Harris, Mobina Khericha, Kenny H. Vo, Minsoo Kim, Chi-Hong Tseng, Yvonne Y. Chen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20221988.
https://doi.org/10.1084/jem.20221988
Published: 12 April 2024
View article titled, Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy
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Includes: Supplementary data