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Journal Articles

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer

Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20240152.
https://doi.org/10.1084/jem.20240152
Published: 27 August 2024
View article titled, Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer
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Includes: Supplementary data
Journal Articles

Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

Naijun Miao, Dongqing Cao, Jingsi Jin, Guizhi Ma, Haihui Yu, Junwen Qu, Guiping Li, Caixia Gao, Dong Dong, Fan Xia, Wenwen Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231486.
https://doi.org/10.1084/jem.20231486
Published: 21 August 2024
View article titled, Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8<sup>+</sup> T cell stemness maintenance
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Includes: Supplementary data
Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

Personalized cancer T-cell therapy takes the stage, mirroring vaccine success

Johanna Chiffelle, Alexandre Harari
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (8): e20240854.
https://doi.org/10.1084/jem.20240854
Published: 11 June 2024
View article titled, Personalized cancer T-cell therapy takes the stage, mirroring vaccine success
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Journal Articles

Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis

In Special Collection:
Mechanisms and Models of Cancer 2024
Lingzi Hong, Tomasz Herjan, Xing Chen, Leah L. Zagore, Katarzyna Bulek, Han Wang, Chi-Fu Jeffrey Yang, Donny D. Licatalosi, Xiaoxia Li, Xiao Li
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20231442.
https://doi.org/10.1084/jem.20231442
Published: 11 June 2024
View article titled, Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis
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Includes: Supplementary data
Journal Articles

Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment

In Special Collection:
Mechanisms and Models of Cancer 2024
Michelle A. Tran, Dina Youssef, Sanjana Shroff, Disha Chowhan, Kristin G. Beaumont, Robert Sebra, Reza Mehrazin, Peter Wiklund, Jenny J. Lin, Amir Horowitz, Adam M. Farkas, Matthew D. Galsky, John P. Sfakianos, Nina Bhardwaj
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (8): e20240045.
https://doi.org/10.1084/jem.20240045
Published: 07 June 2024
View article titled, Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment
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Includes: Supplementary data
Journal Articles

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

In Special Collection:
Immunometabolism 2024 , Mechanisms and Models of Cancer 2024
Yun Xue, Yuting Chen, Sijia Sun, Xinyuan Tong, Yujia Chen, Shijie Tang, Xue Wang, Simin Bi, Yuqin Qiu, Qiqi Zhao, Zhen Qin, Qin Xu, Yingjie Ai, Leilei Chen, Beizhen Zhang, Zhijie Liu, Minbiao Ji, Meidong Lang, Luonan Chen, Guoliang Xu, Liang Hu, Dan Ye, Hongbin Ji
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20240111.
https://doi.org/10.1084/jem.20240111
Published: 28 May 2024
View article titled, TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition
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Includes: Supplementary data
Journal Articles

Hormonal basis of brain fog in cancer treatment

Yuan Pan, Jian Hu
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (5): e20231942.
https://doi.org/10.1084/jem.20231942
Published: 10 April 2024
View article titled, Hormonal basis of brain fog in cancer treatment
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Journal Articles

Divergent local and systemic antitumor response in primary uveal melanomas

In Special Collection:
Mechanisms and Models of Cancer 2024
Francesca Lucibello, Ana I. Lalanne, Anne-Laure Le Gac, Abdoulaye Soumare, Setareh Aflaki, Joanna Cyrta, Lea Dubreuil, Martin Mestdagh, Marion Salou, Alexandre Houy, Christina Ekwegbara, Camille Jamet, Sophie Gardrat, Anais Le Ven, Karine Bernardeau, Nathalie Cassoux, Alexandre Matet, Denis Malaise, Gaelle Pierron, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues, Olivier Lantz
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20232094.
https://doi.org/10.1084/jem.20232094
Published: 02 April 2024
View article titled, Divergent local and systemic antitumor response in primary uveal melanomas
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Includes: Supplementary data
Journal Articles

ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype

In Special Collection:
JEM Cancer Collection 2024
Naveen Sharma, Xiaozhou Fan, Oluwatomisin T. Atolagbe, Zhongqi Ge, Kelly N. Dao, Padmanee Sharma, James P. Allison
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20231263.
https://doi.org/10.1084/jem.20231263
Published: 22 March 2024
View article titled, ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype
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Includes: Supplementary data
Journal Articles

Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds

In Special Collection:
Mechanisms and Models of Cancer 2024
Yuanyuan Zhao, Bing Zhang, Yiming Ma, Mengmeng Guo, Fuqiang Zhao, Jianan Chen, Bingzhi Wang, Hua Jin, Fulai Zhou, Jiawei Guan, Qian Zhao, Qian Liu, Hongying Wang, Fangqing Zhao, Xia Wang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20231359.
https://doi.org/10.1084/jem.20231359
Published: 19 March 2024
View article titled, Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds
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Includes: Supplementary data
Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:
JEM Cancer Collection 2024
Morgan E. Freret, Adrienne Boire
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (4): e20212121.
https://doi.org/10.1084/jem.20212121
Published: 07 March 2024
View article titled, The anatomic basis of leptomeningeal metastasis
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Journal Articles

E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming

In Special Collection:
JEM Cancer Collection 2024
Gengyi Zou, Yuanjian Huang, Shengzhe Zhang, Kyung-Pil Ko, Bongjun Kim, Jie Zhang, Vishwa Venkatesan, Melissa P. Pizzi, Yibo Fan, Sohee Jun, Na Niu, Huamin Wang, Shumei Song, Jaffer A. Ajani, Jae-Il Park
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20230561.
https://doi.org/10.1084/jem.20230561
Published: 27 February 2024
View article titled, E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming
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Includes: Supplementary data
Journal Articles

PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy

In Special Collection:
JEM Cancer Collection 2024 , Cancer Immunotherapy Update 2024
Lei Wang, Yufeng Xiao, Yuewan Luo, Rohan P. Master, Jiao Mo, Myung-Chul Kim, Yi Liu, Chandra K. Maharjan, Urvi M. Patel, Umasankar De, Madison E. Carelock, Tanzia Islam Tithi, Xiangming Li, Donald R. Shaffer, Kevin R. Guertin, Haoyang Zhuang, Emily Moser, Keiran S.M. Smalley, Dongwen Lv, Daohong Zhou, Guangrong Zheng, Weizhou Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (3): e20231519.
https://doi.org/10.1084/jem.20231519
Published: 09 February 2024
View article titled, PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
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Includes: Supplementary data
Journal Articles

EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation

In Special Collection:
JEM Cancer Collection 2024
Zhen Qin, Meiting Yue, Shijie Tang, Fengying Wu, Honghua Sun, Yuan Li, Yongchang Zhang, Hiroki Izumi, Hsinyi Huang, Wanying Wang, Yun Xue, Xinyuan Tong, Shunta Mori, Tetsuro Taki, Koichi Goto, Yujuan Jin, Fei Li, Fu-Ming Li, Yijun Gao, Zhaoyuan Fang, Yisheng Fang, Liang Hu, Xiumin Yan, Guoliang Xu, Haiquan Chen, Susumu S. Kobayashi, Andrea Ventura, Kwok-Kin Wong, Xueliang Zhu, Liang Chen, Shengxiang Ren, Luo-Nan Chen, Hongbin Ji
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (3): e20232028.
https://doi.org/10.1084/jem.20232028
Published: 29 January 2024
View article titled, EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation
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Includes: Supplementary data
Journal Articles

CAR-T cell manufacturing: Major process parameters and next-generation strategies

In Special Collection:
JEM Cancer Collection 2024 , Cancer Immunotherapy Update 2024
Melanie Ayala Ceja, Mobina Khericha, Caitlin M. Harris, Cristina Puig-Saus, Yvonne Y. Chen
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (2): e20230903.
https://doi.org/10.1084/jem.20230903
Published: 16 January 2024
View article titled, CAR-T cell manufacturing: Major process parameters and next-generation strategies
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Journal Articles

MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer

In Special Collection:
Mechanisms and Models of Cancer 2024
Jinhyuk Bhin, Julia Yemelyanenko, Xue Chao, Sjoerd Klarenbeek, Mark Opdam, Yuval Malka, Liesbeth Hoekman, Dinja Kruger, Onno Bleijerveld, Chiara S. Brambillasca, Justin Sprengers, Bjørn Siteur, Stefano Annunziato, Matthijs J. van Haren, Nathaniel I. Martin, Marieke van de Ven, Dennis Peters, Reuven Agami, Sabine C. Linn, Epie Boven, Maarten Altelaar, Jos Jonkers, Daniel Zingg, Lodewyk F.A. Wessels
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (11): e20211743.
https://doi.org/10.1084/jem.20211743
Published: 29 August 2023
View article titled, MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer
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Includes: Supplementary data
Journal Articles

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

In Special Collection:
JEM Cancer Collection 2024 , 2023: The Year in Experimental Medicine
Yang Feng, Qingchen Yuan, Rachel C. Newsome, Troy Robinson, Robert L. Bowman, Ashley N. Zuniga, Kendra N. Hall, Cassandra M. Bernsten, Daniil E. Shabashvili, Kathryn I. Krajcik, Chamara Gunaratne, Zachary J. Zaroogian, Kartika Venugopal, Heidi L. Casellas Roman, Ross L. Levine, Walid K. Chatila, Rona Yaeger, Alberto Riva, Christian Jobin, Daniel Kopinke, Dorina Avram, Olga A. Guryanova
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (11): e20230011.
https://doi.org/10.1084/jem.20230011
Published: 24 August 2023
View article titled, Hematopoietic-specific heterozygous loss of <em>Dnmt3a</em> exacerbates colitis-associated colon cancer
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Includes: Supplementary data
Journal Articles

Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function

In Special Collection:
Tumor Microenvironment and Metastasis 2023
Jianfeng Chen, Xinyi Zhang, Xianming Tan, Pengda Liu
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (10): e20222056.
https://doi.org/10.1084/jem.20222056
Published: 29 June 2023
View article titled, Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function
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Includes: Supplementary data
Journal Articles

Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes

In Special Collection:
Tumor Microenvironment and Metastasis 2023 , JEM Cancer Collection 2024 , Lymphatic Vessels in Health and Disease 2024 , 2023: The Year in Experimental Medicine
Pin-Ji Lei, Ethel R. Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan J. O’Melia, Hengbo Zhou, Sampurna Chatterjee, William W. Ho, Jessica M. Posada, Ashwin S. Kumar, Satoru Morita, Lutz Menzel, Charlie Chung, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20221847.
https://doi.org/10.1084/jem.20221847
Published: 21 June 2023
View article titled, Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes
Open the PDF for Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes in another window
Includes: Supplementary data